PMID: 8581319Jan 1, 1995Paper

Isolation of a compound from Eupatorium adenophorum (Spreng.) [Ageratina adenophora (Spreng.)] causing hepatotoxicity in mice

Natural Toxins
P B OelrichsJ C Ng

Abstract

Regular ingestion of Eupatorium adenophorum [Ageratina adenophora (Spreng.)] or Crofton weed causes chronic pulmonary disease in horses mainly in Australia, New Zealand, and the Himalayas. The disease is characterized by pulmonary interstitial fibrosis, emphysema, alveolar epithelisation and reduced tolerance to exercise. Horses apparently are the only animals affected and there are numerous reports of farms losing all their horses. The disorder was produced experimentally in horse feeding trials, and it was shown that characteristic lesions occurred in the lungs. In studies with laboratory animals, mice were shown to be suitable test animals, but in this species lesions occur in the liver rather than the lungs. The hepatic injury in these animals is characterized by multiple areas of focal necrosis of the parenchyma associated with degeneration and loss of the epithelium lining the small bile ducts. The active principle 9-oxo-10,11 dehydroagerophorone responsible for these lesions in mice has been isolated from E. adenophorum. Although the compound has been shown to exhibit toxicity to larvae of invertebrate species, no mammalian toxicity studies have been previously reported involving the isolated toxin. The mechanism of the ...Continue Reading

Citations

Feb 9, 2000·Toxicon : Official Journal of the International Society on Toxinology·R KatochN P Kurade
Dec 17, 2014·Natural Products and Bioprospecting·Can-Bin OuyangMei-Xia Guo
Nov 26, 2013·Toxicon : Official Journal of the International Society on Toxinology·Fei LiaoYanchun Hu
Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Boyan LiuBing Zhao
Jul 27, 2017·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Quan MoYanchun Hu
Aug 13, 2017·Journal of Applied Microbiology·D SharmaB Singh
Sep 15, 2017·Archives of Toxicology·Tomáš ZárybnickýLenka Skálová
Apr 27, 2021·Natural Product Research·Xu LiangJingquan Yuan

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