Isolation of a family of organic anion transporters from human liver and kidney

Biochemical and Biophysical Research Communications
W SunM D Erion

Abstract

Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and alpha-ketoglutarate. Northern blot analysis indicated differential tissue distribution for the transporter transcripts. These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters.

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·W SunM Montal
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B HagenbuchP J Meier
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·E JacqueminP J Meier
Jun 1, 1996·Kidney International·J B Pritchard, D S Miller
Jul 25, 1997·The Journal of Biological Chemistry·T SekineH Endou
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·B NoéP J Meier
Dec 31, 1997·The Journal of Biological Chemistry·D H SweetJ B Pritchard
Apr 29, 1998·Annual Review of Physiology·H Koepsell
Oct 8, 1998·Kidney & Blood Pressure Research·G ReidG Burckhardt

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Citations

Feb 15, 2011·Pharmacogenetics and Genomics·Torben S MikkelsenRuss B Altman
Apr 1, 2004·Clinical and Experimental Pharmacology & Physiology·Yuai LiAryeh Hurwitz
Jan 25, 2008·Molecular Pharmacology·Cheryl D CroppKathleen M Giacomini
Jan 28, 2010·Pharmacological Reviews·Curtis D Klaassen, Lauren M Aleksunes
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Yoshihisa ShitaraYuichi Sugiyama
Feb 5, 2002·Annual Review of Physiology·Frans G M RusselRemon A M H van Aubel
Jul 22, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Amy G AslamkhanJohn B Pritchard
Mar 24, 2006·Nephron. Physiology·Vincent Launay-VacherGilbert Deray
Mar 2, 2010·Biological & Pharmaceutical Bulletin·Masanobu SatoIkumi Tamai
Jan 5, 2011·Biological Chemistry·Shivangi GuptaYohannes Hagos
May 31, 2011·Pharmacogenomics·Bruno Stieger, Peter J Meier
Jan 10, 2002·Biochemical and Biophysical Research Communications·Yasuna KobayashiToshinori Yamamoto
Nov 8, 2013·BioMed Research International·María Herminia HazelhoffAdriana Mónica Torres
May 17, 2011·Annual Review of Nutrition·Rongbao ZhaoI David Goldman
Aug 16, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aurea LimaVítor Seabra
Mar 20, 2010·Canadian Journal of Physiology and Pharmacology·Matthias RödigerAndrew Bahn
Mar 14, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Brandon SwiftKim L R Brouwer
Jul 10, 2012·Expert Opinion on Drug Metabolism & Toxicology·Andrea TrevisanPatrizia Cristofori
Jul 25, 2006·Expert Opinion on Drug Metabolism & Toxicology·Meng LiJoanne Wang
Mar 4, 2005·Critical Reviews in Toxicology·Evelyn O'Brien, Daniel R Dietrich
Jan 1, 2008·Toxicology Mechanisms and Methods·Peter Ward
Apr 25, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R Nakagomi-HagiharaT Tokui
Mar 20, 2013·Molecular Aspects of Medicine·Hermann Koepsell
Jul 31, 2012·Pharmacology & Therapeutics·Gerhard Burckhardt
Sep 22, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Katsuaki ItoAkira Tsuji
May 20, 2005·The Journal of Pharmacy and Pharmacology·Yasuna KobayashiToshinori Yamamoto
Feb 3, 2011·Medicinal Research Reviews·Pedro Cano-Soldado, Marçal Pastor-Anglada
Oct 22, 2011·British Journal of Pharmacology·Megan RothBruno Hagenbuch
Dec 3, 2009·Biopharmaceutics & Drug Disposition·Adam L VanWertDouglas H Sweet
Apr 23, 2005·Toxicology and Applied Pharmacology·Douglas H Sweet
Nov 9, 2004·Trends in Pharmacological Sciences·Hiroki MiyazakiHitoshi Endou
Dec 31, 2002·Biochemical and Biophysical Research Communications·Satish A EralySanjay K Nigam
Nov 1, 2005·European Journal of Pharmacology·Yasuna KobayashiToshinori Yamamoto
Sep 20, 2005·Pharmacology & Therapeutics·Eliza E Robertson, Gary O Rankin
Jan 1, 2012·Scientifica·Jose J G Marin
Jan 18, 2006·Drug Metabolism and Pharmacokinetics·Masuhiro Nishimura, Shinsaku Naito
Jan 16, 2008·Biochimica Et Biophysica Acta·Jittima Weerachayaphorn, Ana M Pajor
Jun 27, 2006·Journal of Pharmacological Sciences·Naohiko AnzaiHitoshi Endou
Oct 10, 2002·Biochemical and Biophysical Research Communications·Satish A Eraly, Sanjay K Nigam

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