Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25

Gene
T D BuiA L Harris

Abstract

The Wnt gene family has a role in development as well as tumourigenesis. One mouse member, Wnt7a, is vital for limb development in vivo and also possesses transforming ability in vitro. This study reports the isolation of a full length of human homologue of mouse Wnt7a gene by library screening. Yeast artificial chromosome-fluorescence in situ hybridisation (YAC-FISH) mapped the WNT7A gene to chromosome 3p25. Human WNT7A had an ORF encoding a deduced protein of 349 aa that exhibited 97% and 92% identity to mouse Wnt7a at the aa and nucleic acid levels, respectively. It possessed the 22 conserved cysteine residues and 3 more at the amino terminus, and a putative poly A tail. This is the fifth human WNT gene in which a complete cDNA sequence had been determined.

References

Jun 26, 1992·Cell·R Nusse, H E Varmus
Nov 1, 1994·Nature Genetics·G CollodC Boileau
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·F S LeeP Leder
Sep 1, 1994·Molecular and Cellular Biology·G T WongA P McMahon
Jan 15, 1996·The Journal of Clinical Investigation·T M Olson, M T Keating

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Citations

Sep 2, 1998·International Journal of Cancer. Journal International Du Cancer·Z ZhouS Linder
Oct 11, 2003·Journal of Pediatric and Adolescent Gynecology·L S TimmreckM R Gray
Jun 21, 2001·Biochemical and Biophysical Research Communications·T SaitohM Katoh
Dec 20, 2011·Fertility and Sterility·Yujie DangZi-Jiang Chen
Sep 25, 2007·Fertility and Sterility·Ching-Wen ChengD Stephen Charnock-Jones
Jan 31, 2008·Biochemical and Biophysical Research Communications·Kendra S Carmon, David S Loose
Jun 14, 2013·BioMed Research International·Loukia N LiliJohn F McDonald
Jun 20, 1998·Experimental Cell Research·D J Olson, D M Gibo
Jul 5, 2019·Journal of Cellular Biochemistry·Lihui LanChenghai Zhao
Jan 29, 2016·Nature Reviews. Molecular Cell Biology·Yishai AviorNissim Benvenisty
Jan 25, 2002·Annals of the New York Academy of Sciences·S Li, J A McLachlan
Jan 12, 2008·Molecular Cancer Therapeutics·Alain B TchagangAmy P N Skubitz

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