PMID: 9174205Jun 1, 1997Paper

Isolation of a gene encoding a novel spectinomycin phosphotransferase from Legionella pneumophila

Antimicrobial Agents and Chemotherapy
T M SuterNicholas P Cianciotto

Abstract

A gene capable of conferring spectinomycin resistance was isolated from Legionella pneumophila, the agent of Legionnaires' disease. The gene (aph) encoded a 36-kDa protein which has similarity to aminoglycoside phosphotransferases. Biochemical analysis confirmed that aph encodes a phosphotransferase which modifies spectinomycin but not hygromycin, kanamycin, or streptomycin. The strain that was the source of aph demonstrated resistance to spectinomycin, and Southern hybridizations determined that aph also exists in other legionellae.

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Citations

Apr 19, 2000·Antimicrobial Agents and Chemotherapy·M GalimandP Courvalin
Aug 30, 2007·PloS One·Stephen B Beres, James M Musser
Jul 15, 2003·Clinical Microbiology Reviews·Sergei B Vakulenko, Shahriar Mobashery
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Jan 29, 2021·The Journal of Antibiotics·Suresh DharumanRichard E Lee
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Sep 14, 2010·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Maria S Ramirez, Marcelo E Tolmasky

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