PMID: 6406640Jun 1, 1983Paper

Isolation of a high molecular weight polyphosphate from Neisseria gonorrhoeae

The Journal of Experimental Medicine
A Noegel, E C Gotschlich

Abstract

Neisseria gonorrhoeae, as well as other Neisseriae, produce polyphosphate. This polyphosphate exists in two forms. Approximately half of it is loosely associated with the cells and can be recovered by washing in neutral buffers under conditions in which no significant lysis of the cells is observed. The other half is either intracellular or tightly associated, because it requires digestion of the cells with perchloric acid or sodium hypochlorite. Polyphosphate obtained by both methods was purified by column chromatography and chemically characterized. In contrast to other organisms, gonococci do not respond with increased polyphosphate synthesis when shifted from phosphate starvation to a phosphate-rich medium. In addition, gonococcal polyphosphate does not serve as a depletable phosphate source during phosphate starvation. All strains of Neisseriae examined produce substantial amounts of polyphosphate.

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Citations

Jun 27, 1985·The New England Journal of Medicine·B E BritiganP F Sparling
Aug 26, 2010·The Journal of Biological Chemistry·Qian ZhangChristoph M Tang
Feb 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·B LorenzH C Schröder
Dec 17, 2009·Journal of Proteomics·Hsing-Ju WuMichael P Jennings
May 11, 2013·Journal of Thrombosis and Haemostasis : JTH·C PuyO J T McCarty
May 20, 2015·Macromolecular Bioscience·Werner E G MüllerXiaohong Wang
Aug 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K ReimannJ Blom
Oct 8, 2005·Seminars in Pediatric Infectious Diseases·Charles R Woods
Mar 1, 1984·The Veterinary Clinics of North America. Small Animal Practice·K Flammer
Apr 25, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephanie A Smith, James H Morrissey
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Jevgenia Zilberman-RudenkoOwen J T McCarty
Jan 19, 2019·Research and Practice in Thrombosis and Haemostasis·Catherine J BakerJames H Morrissey
Aug 14, 2020·Nature Communications·Julian RoeweMarkus Bosmann
Feb 27, 2021·Trends in Microbiology·Marvin Q Bowlin, Michael J Gray
Sep 1, 1993·Infection and Immunity·C R TinsleyE C Gotschlich
Jul 1, 1984·Journal of Bacteriology·W J ToddP J Hitchcock
Apr 1, 1988·Infection and Immunity·W R McKennaD W Dyer

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