Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity

Organic Letters
Carolyn A BrothertonEmily P Balskus

Abstract

Colibactin is a structurally uncharacterized, genotoxic natural product produced by commensal and pathogenic strains of E. coli that harbor the pks island. A new metabolite has been isolated from a pks(+) E. coli mutant missing an essential biosynthetic enzyme. The unusual azaspiro[2.4] bicyclic ring system of this molecule provides new insights into colibactin biosynthesis and suggests a mechanism through which colibactin and other pks-derived metabolites may exert genotoxicity.

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Feb 10, 2016·Current Opinion in Chemical Biology·Srividhya Sundaram, Christian Hertweck
Aug 31, 2016·Nature Microbiology·Jarrod J MousaChristian Jobin
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Jan 24, 2019·Journal of Industrial Microbiology & Biotechnology·Matt McErleanSteven Van Lanen
Aug 15, 2017·Nature Chemical Biology·Li ZhaEmily P Balskus

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