PMID: 8968667Dec 1, 1996Paper

Isolation of a non-steroidal contragestative agent from Sri Lankan marine red alga, Gelidiella acerosa

Contraception
G A PremakumaraL M Tillekeratne

Abstract

This study reports the isolation of a non-steroidal contragestative agent from the Sri Lankan marine red alga, Gelidiella acerosa. One-hundred grams of MeOH-CH2Cl2 (1:1) crude extract of G. acerosa was initially partitioned into hexane, CH2Cl2 and EtOAc, respectively, using the modified Kupchan scheme. At each separation step, all the resulting fractions were tested for contragestative effects in pregnant rats. The fertility was assessed in terms of the number of viable implants following oral administration of fractions (co-precipitated with polyvinylpyrrolidone), on day 1 through day 7 of pregnancy. The hexane fraction with highest activity was subjected to gel filtration through Sephadex LH-20, vacuum liquid chromatography over TLC-grade silica, two open-column chromatography runs over silica gel (60-120 mesh), and HPLC to isolate the active component. Nuclear magnetic resonance and infrared spectroscopic analysis revealed that the contragestative agent of G. acerosa is a sphingosine derivative.

References

Sep 1, 1989·Journal of Natural Products·L M TillekeratneF J Schmitz
Sep 1, 1994·Contraception·W D RatnasooriyaL M Tillekeratne
May 1, 1982·Planta medica·B N MeyerJ L McLaughlin

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Citations

Jan 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Arif Nisha SyadPandima Devi Kasi
Apr 6, 2013·Andrologia·S PrakashE Kannapiran
Jun 30, 2018·Journal of Dietary Supplements·Arif Nisha Syad, Kasi Pandima Devi
Jul 23, 2020·Journal of Complementary & Integrative Medicine·Ejaz AzizMohammad Ali Shariati

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