PMID: 11918058Mar 29, 2002Paper

Isolation of a novel cyclic hexadepsipeptide pipalamycin from Streptomyces as an apoptosis-inducing agent

The Journal of Antibiotics
Y UchihataK Umezawa

Abstract

The novel cyclic hexadepsipeptide named pipalamycin was isolated from a culture filtrate of Streptomyces sp. ML297-90F8 as an apoptosis-inducing agent. The antibiotic was found to be consisting of each one mole of alanine, N-hydroxyalanine, glycine, N-acylated 3-hydroxyleucine, and two moles of piperazic acid. Pipalamycin induced apoptosis in apoptosis-resistant human pancreatic adenocarcinoma AsPC-1 cells at 0.3 microg/ml in 24 to approximately 48 hours. It also showed antibacterial activity on Gram-positive bacteria such as Staphylococcus aureus and Micrococcus luteus. Fermentation, isolation, structural elucidation and the biological activities of pipalamycin are described.

Citations

Jan 28, 2005·The New England Journal of Medicine·George A Jacoby, Luisa Silvia Munoz-Price
Jul 2, 2005·Angewandte Chemie·K C NicolaouDavid Sarlah
Jul 6, 2014·Beilstein Journal of Organic Chemistry·Oliver RiesChristian Ducho
Sep 30, 2005·Chemical Communications : Chem Comm·Jacques-Alexis FunelJoëlle Prunet
Nov 18, 2014·Angewandte Chemie·Jeffrey Y W MakCraig M Williams
Apr 6, 2019·Natural Product Reports·Kalindi D MorganKatherine S Ryan
Jul 2, 2003·Amino Acids·Y L Janin
Dec 1, 2008·Indian Journal of Microbiology·Renu SolankiRup Lal
May 27, 2004·Natural Product Reports·Hideaki Oikawa, Tetsuo Tokiwano
May 8, 2007·Organic Letters·Geoff T Halvorsen, William R Roush
Dec 4, 2003·Journal of the American Chemical Society·Ryosuke MunakataKin-ichi Tadano
Dec 28, 2002·Journal of Natural Products·Kazuo UmezawaShinichi Kondo
Dec 15, 2005·Chemical Reviews·Ken-Ichi TakaoKin-ichi Tadano
Jun 19, 2004·The Journal of Organic Chemistry·Jacques-Alexis Funel, Joëlle Prunet

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis