Isolation of a novel gene down-regulated by v-src

FEBS Letters
J PanA Hakura

Abstract

We have isolated a novel gene which was expressed in normal rat cells, but completely suppressed in cells transformed by v-src. The molecularly cloned cDNA was about 1.8 kb in size, containing an open reading frame composed of 464 amino acid residues. DNA sequence analysis showed that there was no corresponding gene in the data bases. Besides the suppression of gene expression in the v-src transformed cells, its expression was also strongly suppressed in cells transformed by other oncogenes such as v-abl, v-fps, v-mos, v-sis, v-K-ras, and polyomavirus middle T, but not affected in cells transformed by human papillomavirus type 16 E6E7 and polyomavirus large T. We named the gene drs for a gene down-regulated by v-src.

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Citations

Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·M ShimakageH Inoue
Jun 7, 2002·Cancer Letters·Takao KawaiHirokazu Inoue
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Oct 11, 2011·Cancer Letters·Yukihiro TambeHirokazu Inoue
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Dec 18, 2019·International Journal of Molecular Sciences·Eros Di GiorgioClaudio Brancolini
Mar 14, 1998·Journal of Virology·H InoueA Hakura

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