Isolation of a novel subgroup B feline leukemia virus from a cat infected with FeLV-A

S BoomerJ Overbaugh


Proviruses were cloned directly from a cat that developed neurological disorders approximately 28 months after inoculation with a molecularly cloned, minimally pathogenic subgroup A feline leukemia virus (FeLV-A). In addition to FeLV-A proviruses that were nearly identical to the inoculated virus, we detected a subgroup B-like variant in brain, bone marrow, and lymph node that apparently had acquired the major portion of its extracellular envelope gene (gp70) from endogenous FeLV-related sequences. A similar recombinant was also detected, by PCR, at low levels in bone marrow from an early time postinfection (2.5 months). A full-length proviral variant with this recombinant structure cloned from brain tissue encoded a replication-defective virus. A chimera encoding the 5' gag-pol portion of FeLV-A and the 3' env-LTR portion of the defective brain-derived clone was replication-competent and had the extended host range properties of FeLV-B.


Dec 28, 2012·Journal of Virology·Ramon MendozaJ Overbaugh
Oct 17, 2001·Journal of Virology·M M AndersonJ Overbaugh
Mar 16, 2006·Journal of Virology·Ramon MendozaJ Overbaugh
Apr 22, 2015·Virus Research·Maki KawamuraKazuo Nishigaki
Feb 28, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Keith Bupp, Monica J Roth
Sep 24, 2002·Veterinary Pathology·K P CarmichaelJ J McDonnell
Mar 29, 2002·Journal of Feline Medicine and Surgery·H LutzR Hofmann-Lehmann

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