PMID: 9417916Jan 7, 1998Paper

Isolation of a pancreas-specific gene located on human chromosome 14q31: expression analysis in human pancreatic ductal carcinomas

Genomics
I BiunnoV Sgaramella

Abstract

We have isolated a novel cDNA (SEL1L) that shows sequence similarities to SEL-1, a gene identified as an extragenic suppressor of the lin-12 hypomorphic mutant from Caenorhabditis elegans (7, 8). SEL1L exhibits a tissue-specific pattern of expression: a single poly(A)+ RNA species of 7.5 kb is abundantly expressed only in the pancreas of healthy individuals, whereas low to undetectable levels are observed in other adult and in some fetal tissues. Somatic hybrid panel and fluorescence in situ hybridization positioned this gene in the q31 band of human chromosome 14. The tissue-specific expression of this gene induced us to study its role in human pancreatic carcinomas. Our analysis revealed that 17% of adenocarcinomas of the pancreas did not express SEL1L to a detectable level; however, no gross genomic alterations were apparent in the few hundred kilobases of the relevant region.

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Citations

Aug 19, 2006·Cell Death and Differentiation·T LiuK G Wiman
Feb 11, 2009·The Journal of Biological Chemistry·Monica CattaneoIda Biunno
Aug 17, 2004·DNA and Cell Biology·Giuseppe DiaferiaIda Biunno
May 15, 2001·Thyroid : Official Journal of the American Thyroid Association·Y BanY Ban
Jul 30, 2002·Omics : a Journal of Integrative Biology·Ida BiunnoMonica Cattaneo
Nov 13, 2010·Cancer Prevention Research·Seetharaman BalasenthilAnn McNeill Killary
Feb 23, 2010·BMC Developmental Biology·Shuai LiQiaoming Long
Sep 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Brendan N Lilley, Hidde L Ploegh
Oct 18, 2006·The Journal of Cell Biology·Britta MuellerHidde L Ploegh
Dec 7, 2005·Journal of Cellular Physiology·Ida BiunnoSylvie Ménard
May 2, 2006·Human Pathology·Stefano FerreroIda Biunno
Dec 22, 1998·Mechanisms of Development·D B DonovielA Bernstein
Sep 7, 2001·Diabetes/metabolism Research and Reviews·F PociotF Cucca
Sep 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paola GranelliIda Biunno

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