PMID: 590934Dec 1, 1977

Isolation of a protease inhibitor from tissues resistant to tumor invasion

Hoppe-Seyler's Zeitschrift für physiologische Chemie
D B Rifkin, R M Crowe


We have purified to homogeneity the major trypsin inhibitors from both bovine cartilage and aorta, two tissues reported to be highly resistant to invasion. The two inhibitors appear to be identical and they resemble the Kunitz inhibitor with respect to molecular weight, amino acid composition, range of susceptible proteases, and antigenicity. Each of these inhibitors accounts for 100% of the antitrypsin activity found in extracts of bovine cartilage and aorta.


Sep 7, 1976·Biochemical and Biophysical Research Communications·K E KuettnerE Harper
Aug 16, 1965·Biochemical and Biophysical Research Communications·B Kassell, M Laskowski


Jan 1, 1983·Cancer Metastasis Reviews·B U PauliK E Kuettner
Jan 1, 1988·Archives of Dermatological Research·D BarszczW Gliński
Mar 1, 1988·Clinical & Experimental Metastasis·E PrangeH Pralle
Feb 1, 1983·Applied Biochemistry and Biotechnology·R Langer, J Murray
Jan 1, 1980·The International Journal of Biochemistry·D M Kirschenbaum
Jan 1, 1991·Pharmacology & Therapeutics·R Eisenstein
Apr 1, 1984·Urology·B U Pauli, K E Kuettner
Sep 1, 1983·Collagen and Related Research·J J KillackeyJ S Mort
Mar 1, 1984·The Journal of Cell Biology·L I LarssonK Danø
Dec 1, 1979·American Journal of Ophthalmology·R EisensteinE Choromokos
Jun 1, 1981·The American Journal of Medicine·M B Sporn, E D Harris
Jul 1, 1983·Medical Hypotheses·W F Long, F B Williamson
Jul 1, 1983·The American Journal of Medicine·H DashG B Martin
Jan 1, 1980·Journal of Supramolecular Structure·V B HatcherP G Burk
Jan 1, 1981·Developmental and Comparative Immunology·M A Wainberg, S D Cohen
Dec 15, 1987·International Journal of Cancer. Journal International Du Cancer·M RezaeeR H Kramer
Aug 1, 1987·Journal of Neurosurgery·R SawayaR Highsmith
May 1, 1983·British Journal of Pharmacology·D Rohozková, F S Steven
Aug 1, 1982·European Journal of Biochemistry·F S StevenS Itzhaki
Jul 1, 1991·Clinical & Experimental Metastasis·W SchroyensL De Ridder
May 15, 1984·International Journal of Cancer. Journal International Du Cancer·O SakselaS Barlati

Related Concepts

Ascending Aorta Structure
Bos indicus
Protease Inhibitors
Trypsin Inhibitor, Kunitz Soybean
Trypsin Inhibitors

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