Isolation of a reovirus from poult enteritis and mortality syndrome and its pathogenicity in turkey poults

Avian Diseases
C L Heggen-PeayKarel Antoni Schat

Abstract

Poult enteritis and mortality syndrome (PEMS) is an acute, infectious intestinal disease of turkey poults, characterized by high mortality and 100% morbidity, that decimated the turkey industry in the mid-1990s. The etiology of PEMS is not completely understood. This report describes the testing of various filtrates of fecal material from control and PEMS-affected poults by oral inoculation into poults under experimental conditions, the subsequent isolation of a reovirus, ARV-CU98, from one of the PEMS fecal filtrates, and in vivo and in vitro studies conducted to determine the pathogenicity of ARV-CU98 in turkey poults. In order to identify a filtrate fraction of fecal material containing a putative etiologic agent, poults were challenged in two independent experiments with 220- and 100-nm filtrates of fecal material from PEMS-negative and PEMS-positive poults. The 100-nm filtrate was chosen for further evaluation because poults inoculated with this filtrate exhibited mortality and significantly lower (P < or = 0.05) body weight and relative bursa weight, three clinical signs associated with PEMS. These results were confirmed in a third experiment with 100-nm fecal filtrates from a separate batch of PEMS fecal material. In Exp...Continue Reading

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Citations

Dec 26, 2013·Virus Genes·Liqiong TengMazhar I Khan
Dec 12, 2013·Archives of Virology·Ana Carolina G RosaTereza Cristina Cardoso
Feb 13, 2015·Virusdisease·Naresh JindalSagar M Goyal
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Apr 7, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Dan LuoXiaomei Wang

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Methods Mentioned

BETA
flow cytometry
electrophoresis
enzyme-linked immunosorbent assay
electron microscopy

Software Mentioned

SAS

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