Isolation of antagonists of antigen-specific autoimmune T cell proliferation.

Chemistry & Biology
Anne GockeThomas Kodadek

Abstract

Antigen-specific T cells play a major role in mediating the pathogenesis of a variety of autoimmune conditions as well as other diseases. In the context of experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis, we present here a general approach to the discovery of highly specific ligands for autoreactive cells. These ligands are obtained from a combinatorial library of hundreds of thousands of synthetic peptoids that is screened simultaneously against two populations of CD4+ T cells. Peptoids that recognize autoreactive T cells with extremely high specificity can be identified in the library. Since no specific knowledge is required regarding the nature of the native antigens recognized by the autoreactive T cells, this technology provides a powerful tool for the enrichment and inhibition of autoimmune cells in a variety of disease states.

References

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Citations

May 26, 2011·Molecular BioSystems·Melissa M LeeMatthew D Disney
Aug 3, 2010·Current Opinion in Chemical Biology·Thomas Kodadek
Oct 29, 2015·ACS Chemical Biology·Jaya M MatharageD Gomika Udugamasooriya
Sep 23, 2014·Chemistry & Biology·Thomas Kodadek
Apr 27, 2016·Journal of the American Chemical Society·Todd M DoranThomas Kodadek
Jun 30, 2016·ACS Chemical Biology·Kimberly D BarnashLindsey I James
Mar 22, 2016·Chemical Communications : Chem Comm·Thomas Kodadek, Patrick J McEnaney
Oct 22, 2019·Chemical Communications : Chem Comm·Thomas KodadekPaige Dickson
May 15, 2012·Current Protocols in Chemical Biology·D Gomika Udugamasooriya, Thomas Kodadek
Jun 4, 2016·Biopolymers·Jaspal SinghD Gomika Udugamasooriya
Jul 26, 2012·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Martin HintersteinerManfred Auer
Oct 7, 2021·Chemical Communications : Chem Comm·Claudine Nicole HerlanStefan Bräse

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