Oct 28, 2004

Isolation of anti-ulcerogenic sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis through bioassay-guided fractionation procedures in rats

Journal of Ethnopharmacology
Erdem YesiladaIkhlas A Khan

Abstract

The fresh spiny flowers of Centaurea solstitialis ssp. solstitialis (CSS) are used for the treatment of peptic ulcers in Turkey. Ethanol (80%) extract of CSS exhibited significant anti-ulcerogenic effect on the ethanol-induced ulcerogenesis model in rats. The ethanol extract was further fractionated by successive solvent extractions with n-hexane, chloroform, ethyl acetate and n-butanol. All fractions showed significant anti-ulcerogenic activity, however, the effect of the chloroform fraction was found to be more prominent with 99.5% ulcer inhibition. Bioassay-guided fractionation yielded sesquiterpene lactones as the active components. The main components responsible for the activity of the chloroform fraction were determined as chlorojanerin and 13-acetyl solstitialin A which were elucidated by HR-ESI and (1)H, (13)C and 2D NMR spectroscopic techniques.

Mentioned in this Paper

Peptic Ulcer
Ethanol
n-hexane
Anti-Ulcer Agent
Plant Carpals
Ethanol Measurement
Gastric Ulcer
Centaurea solstitialis
Helicobacter pylori
Cyclopentenone

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