Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.

Marine Drugs
Takayuki OgiKatsuhiro Ueda

Abstract

A series of new C(11) cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).

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Citations

Jun 21, 2012·The Journal of Organic Chemistry·Justyna SikorskaKerry L McPhail
Dec 5, 2014·Marine Drugs·Ri-Ming HuangYan Peng
Mar 13, 2012·Drug Discovery Today·Edwin L Cooper, David Yao
Mar 5, 2011·Biotechnology Advances·Marc SchumacherMarc Diederich
Nov 6, 2010·Current Opinion in Biotechnology·Eric W Schmidt, Mohamed S Donia
Apr 22, 2016·Chemical Reviews·Svilen P SimeonovCarlos A M Afonso
May 28, 2014·Journal of Asian Natural Products Research·Xiang-Jing WangWen-Sheng Xiang
Sep 8, 2016·The Journal of Antibiotics·Mei-Yue GaoWen-Sheng Xiang
Jan 18, 2017·Natural Products and Bioprospecting·Satheesh Kumar PalanisamyAngela Marino
Oct 14, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marc SchumacherMarc Diederich
Dec 6, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tamanna RobKatsuhiro Ueda
Dec 15, 2010·Natural Product Reports·John W BluntMichèle R Prinsep

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Methods Mentioned

BETA
X-ray
NMR
Circular Dichroism

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