PMID: 11342040May 9, 2001Paper

Isolation of chymase complexed with physiological inhibitor similar to secretory leukocyte protease inhibitor (SLPI) from hamster cheek pouch tissues

Biochimica Et Biophysica Acta
K TakaoM Miyazaki

Abstract

A low molecular weight protein complexed with chymase was isolated from hamster cheek pouch tissues. This protein had an apparent molecular mass of about 10 kDa on SDS-PAGE and the N-terminal sequence showed some homology to secretory leukocyte protease inhibitor (SLPI), which is known as the predominant inhibitor of neutrophil elastase and cathepsin G. Remarkably enhanced inhibition of chymase activity was achieved in the presence of heparin, indicating that the functional property was also similar to SLPI. These findings suggest that this SLPI-like protein is a candidate for a physiological inhibitor of chymase.

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Citations

Jul 19, 2001·Japanese Journal of Pharmacology·D JinM Miyazaki
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Beril TomA H Jan Danser
Nov 6, 2007·The Journal of Biological Chemistry·Jukka KervinenJohn Spurlino
Oct 15, 2020·International Journal of Molecular Sciences·Kentaro TeraiShinji Takai

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