Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of gelsemium alkaloids for A431 epidermoid carcinoma cells

Journal of Natural Products
Mariko KitajimaHiromitsu Takayama

Abstract

Four new gelsedine-type indole alkaloids (1-4) were isolated from the leaves of Gelsemium elegans, together with 11 known alkaloids. The structures were determined as 14-acetoxygelsenicine (1), 14-acetoxy-15-hydroxygelsenicine (2), 14-hydroxy-19-oxogelsenicine (3), and 14-acetoxygelselegine (4), respectively, by spectroscopic analysis. The cytotoxic effects of 14 Gelsemium alkaloids including two new compounds (1, 2) were evaluated using the A431 human epidermoid carcinoma cell line. Of these, the gelsedine-type alkaloids 14-acetoxy15-hydroxygelsenicine (2) [corrected] 14,15-dihydroxygelsenicine (5), gelsedine (7), and gelsemicine (8) showed potent cytotoxic effects.

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Citations

Nov 22, 2013·Journal of Natural Products·Jing QuShuang-Gang Ma
Jun 4, 2008·Chemical & Pharmaceutical Bulletin·Noriyuki KogureHiromitsu Takayama
Jul 1, 2010·Pharmacognosy Reviews·V DuttA Sharma
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Jul 30, 2015·Journal of Natural Products·Wei ZhangWen-Cai Ye
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Oct 21, 2010·Chemistry, an Asian Journal·Yousuke YamadaHiromitsu Takayama
Jul 8, 2008·Chemistry, an Asian Journal·Sheng YinJian-Min Yue
Nov 1, 2018·Angewandte Chemie·Ankan Ghosh, Rich G Carter
May 28, 2009·Natural Product Reports·Minoru Ishikura, Koji Yamada
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Jan 9, 2020·Journal of Asian Natural Products Research·Qiang XueJun Gu
Nov 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Evgeny ChupakhinMikhail Krasavin
Jun 20, 2015·Acta Crystallographica. Section E, Crystallographic Communications·Man ZhangDa-Zhi Li
Apr 14, 2015·Journal of the American Chemical Society·Stefan Diethelm, Erick M Carreira
Oct 11, 2011·Journal of the American Chemical Society·Jun ShimokawaTohru Fukuyama
Aug 28, 2021·Chemical Reviews·Tomáš NeveselýRyan Gilmour
Jun 30, 2006·Organic Letters·Noriyuki KogureHiromitsu Takayama

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