PMID: 6781553Dec 1, 1980

Isolation of high affinity antibodies to streptococcal group A polysaccharide reacting with thymus and cutaneous epithelial cells

Biulleten' eksperimental'noĭ biologii i meditsiny
V Iu KolesnikovaI M Liampert

Abstract

Anti-streptococcal A polysaccharide (anti-A polysaccharide) antibodies were isolated from sera of rabbits immunized with group A streptococci by means of immunosorbents. The antibodies were studied by indirect immunofluorescence method on sections of skin and thymus tissues. Most preparations of high affinity antibodies reacting with A polysaccharide in the immunodiffusion test also react with skin and thymus epithelial cells. No preparations of low affinity anti-A polysaccharide antibodies reacted with thymus or skin epithelium. It was found that the reaction of antibodies to A-polysaccharide with epithelial cells does not depend on the availability of antibodies cross reacting with group L streptococcal polysaccharide. The reaction with thymus and skin epithelial cells is likely to be bound with high affinity antibodies to the specific determinant of A-polysaccharide.

References

Jan 1, 1977·Journal of Immunological Methods·G Johnson, J S Garvey
Feb 1, 1976·Biulleten' eksperimental'noĭ biologii i meditsiny·L V BeletskaiaI I Rassokhina
Jan 1, 1975·Scandinavian Journal of Immunology·I M LyampertI I Rassokhina
Jan 28, 1976·Human Genetics·K SperlingG Obe
Feb 1, 1976·Biulleten' eksperimental'noĭ biologii i meditsiny·G N Shmigidina, I N Kudriavtseva
Apr 1, 1966·The Journal of Experimental Medicine·C K OsterlandR M Krause

Related Concepts

Antibody Avidity
Cross Reactions
Mesothelium
Immunofluorescence Assay
Immunodiffusion Measurement
Immunosorbent Techniques
Polysaccharides, Bacterial
Skin
Bacteria, Flesh-Eating
Thymus Gland

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