Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

Phytotherapy Research : PTR
Lasse SaabySøren Brøgger Christensen

Abstract

A previously published systematic review and a metaanalysis have concluded that the consumption of standardized rose hip powder (Rosa canina L.) can reduce pain in osteoarthritis patients. Synovial inflammation has been suggested to play an important role in the pathogenesis of osteoarthritis and mainly to involve infiltration of the synovial membrane by macrophages. Therefore, the immunomodulatory effect of standardized rose hip powder of Rosa canina L. was investigated and active principles isolated using the Mono Mac 6 cell line as a model for human macrophages. Treatment of Mono Mac 6 cells with the residue of a crude dichloromethane extract of rose hip powder significantly and concentration dependently inhibited the lipopolysaccharide induced interleukin-6 release. Through bioassay-guided fractionation the immunomodulatory effect of the dichloromethane extract was correlated to a mixture of three triterpene acids; oleanolic acid, betulinic acid and ursolic acid (IC(50) 21 ± 6 µm). Further studies revealed that only oleanolic acid and ursolic acid, but not betulinic acid, could inhibit the lipopolysaccharide induced interleukin-6 release from Mono Mac 6 cells when tested separately. Combination of either oleanolic acid or u...Continue Reading

References

Mar 15, 1988·International Journal of Cancer. Journal International Du Cancer·H W Ziegler-HeitbrockG Riethmüller
Dec 1, 1993·Annals of the Rheumatic Diseases·M N FarahatG S Panayi
Mar 24, 1998·Immunology Today·M J May, S Ghosh
Aug 11, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E M SchwarzR J O'Keefe
Dec 21, 2000·Current Rheumatology Reports·M B Goldring
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasunari Takada, Bharat B Aggarwal
Mar 26, 2005·Current Medicinal Chemistry·Perumal Yogeeswari, Dharmarajan Sriram
Jan 6, 2006·Phytotherapy Research : PTR·C ChrubasikS Chrubasik
Apr 5, 2008·Phytotherapy Research : PTR·A K JägerS Brøgger Christensen
Aug 19, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E M WenzigR Bauer
Oct 1, 1997·Journal of Clinical Pharmacy and Therapeutics·L MoesbyJ D Christensen
Jun 2, 2009·Lancet·Peter J Barnes, Ian M Adcock
Jun 19, 2009·Atherosclerosis·Changjie SongS Ben Freedman

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Citations

Jul 26, 2012·Oxidative Medicine and Cellular Longevity·C WidénK Rumpunen
Jul 22, 2014·Phytotherapy Research : PTR·S Chrubasik-HausmannU Müller-Ladner
Apr 13, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Sandra JiménezCarmen Ancín-Azpilicueta
Feb 10, 2017·Journal of the Science of Food and Agriculture·Si Jing ChenToshiro Matsui
Aug 7, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Jie LiuCurtis D Klaassen
Nov 10, 2020·Frontiers in Cell and Developmental Biology·José M CastellanoJavier S Perona
May 1, 2021·International Journal of Molecular Sciences·Adelina LombreaCorina Danciu
May 1, 2021·Antioxidants·Mindaugas LiaudanskasValdimaras Janulis
Sep 28, 2012·Journal of Agricultural and Food Chemistry·Christelle M AndreWilliam A Laing

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