PMID: 1206008Dec 1, 1975Paper

Isolation of isoflavones inhibiting DOPA decarboxylase from fungi and streptomyces

The Journal of Antibiotics
H UmezawaK Nakamura

Abstract

By screening of culture filtrates of fungi and streptomyces for activity in inhibit dopa decarboxylase the following isoflavone compounds were obtained: psi-tectorigenen (I), genistein (II), orobol (IV), 8-hydroxygenistein (V) and a new compound (III). III was elucidated to be 3', 4', 5, 7-tetrahydroxy-8methoxy isoflavone. Among these isoflavones, IV and III showed the strongest activity in inhibiting dopa decarboxylase. All these isoflavones also inhibited histidine decarboxylase and catechol-O-methyltrasnferase. Activities of these compounds to inhibit tyrosine hydroxylase and dopamine beta-hydroxylase were examined. Orobol which showed no or only slight inhibition of tyrosine hydroxylase and dopamine beta-hydroxylase exhibited a significant hypotensive effect on spontaneously hypertensive rats.

Citations

Sep 6, 2018·FEMS Microbiology Letters·Pyung-Gang LeeByung-Gee Kim
Sep 17, 2009·Analytical and Bioanalytical Chemistry·Kristian Fog NielsenJens Christian Frisvad
Feb 10, 2006·The Journal of Antibiotics·Yuesheng DongJiangong He
Apr 8, 2014·International Journal of Molecular Sciences·Te-Sheng Chang
Nov 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun-Fei WangShao-Hua Wu
May 22, 2016·Journal of the Neurological Sciences·Erica CassaniGianni Pezzoli
Nov 14, 1978·Biochemical and Biophysical Research Communications·Y WatanabeO Hayaishi

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