Isolation of mutations affecting neural circuitry required for grooming behavior in Drosophila melanogaster.

Genetics
R W PhillisR K Murphey

Abstract

We have developed a screen for the isolation of mutations that produce neural defects in adult Drosophila melanogaster. In this screen, we identify mutants as flies unable to remove a light coating of applied dust in a 2-hr period. We have recovered and characterized six mutations and have found that they produce coordination defects and some have reduced levels of reflex responsiveness to the stimulation of single tactile sensory bristles. The grooming defects produced by all six of the mutations are recessive, and each of the mutations has been genetically mapped. We have also used our assay to test the grooming ability of stocks containing mutations that produce known neural defects.

Citations

Oct 15, 2003·Behavioural Processes·Jean René Martin
Feb 24, 2006·Behavioural Brain Research·Amber E BaumEva E Redei
Jun 1, 2005·Biochimica Et Biophysica Acta·Pauline Phelan
Sep 14, 2004·Journal of Neurobiology·David M Tobin, Cornelia I Bargmann
Aug 13, 2013·G3 : Genes - Genomes - Genetics·Thomas F FloodMotojiro Yoshihara
Nov 20, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Robert R H Anholt
Apr 17, 2007·Pflügers Archiv : European journal of physiology·Maurice J Kernan
Apr 22, 2008·Developmental Biology·Midori J SeppaRoss L Cagan
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Timothy J MoscaHaig Keshishian
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·C YellmanJ Hirsh
Nov 10, 2020·Journal of Neurogenetics·David R AndrewLinda L Restifo
Feb 21, 2016·G3 : Genes - Genomes - Genetics·Lanikea B KingSeth M Tomchik
Jan 21, 2021·Communications Biology·Budhaditya ChowdhuryHerman A Dierick
Feb 13, 2001·Brain Research Bulletin·D E Featherstone, K Broadie
Jun 11, 1999·Journal of Neurobiology·M GorczycaV Budnik
Oct 1, 1998·Behavioural Brain Research·G O Pflugfelder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.