Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis

PLoS Neglected Tropical Diseases
Leticia ZarantonelliGrupo de Trabajo Interinstitucional de Leptospirosis Consortium

Abstract

Leptospirosis is a neglected zoonosis with worldwide distribution. The causative agents are spirochete bacteria of the Leptospira genus, displaying huge diversity of serovars, the identity of which is critical for effective diagnosis and vaccination purposes. Among many other mammalian species, Leptospira infects cattle, eliciting acute signs in calves, and chronic disease in adult animals often leading to abortions. In South America, and including in Uruguay, beef and dairy export are leading sources of national income. Despite the importance of bovine health, food safety, and bovine-related dissemination of leptospirosis to humans, extremely limited information is available as to the identity of Leptospira species and serovars infecting cattle in Uruguay and the South American subcontinent. Here we report a multicentric 3-year study resulting in the isolation and detailed characterization of 40 strains of Leptospira spp. obtained from infected cattle. Combined serologic and molecular typing identified these isolates as L. interrogans serogroup Pomona serovar Kennewicki (20 strains), L. interrogans serogroup Canicola serovar Canicola (1 strain), L. borgpetersenii serogroup Sejroe serovar Hardjo (10 strains) and L. noguchii (9 ...Continue Reading

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Citations

Jan 28, 2019·Transboundary and Emerging Diseases·Camila HamondLeticia Zarantonelli
Apr 27, 2019·PLoS Neglected Tropical Diseases·Julien GuglielminiMathieu Picardeau
Jun 11, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Melissa Macías-RiosecoFederico Giannitti
Jul 26, 2019·Transboundary and Emerging Diseases·Manuel JaraGustavo Machado
Sep 5, 2019·Transboundary and Emerging Diseases·Ana P LoureiroWalter Lilenbaum
Apr 8, 2020·Journal of Veterinary Research·Francesca GrippiAnnalisa Guercio
Nov 23, 2019·Microbiology Resource Announcements·Cecilia NievesGregorio Iraola
Nov 28, 2020·Comparative Immunology, Microbiology and Infectious Diseases·Israel Barbosa GuedesMarcos Bryan Heinemann
Mar 6, 2021·Tropical Animal Health and Production·Israel Barbosa GuedesMarcos Bryan Heinemann
Mar 19, 2021·PLoS Neglected Tropical Diseases·Dinesha JayasundaraJoseph M Vinetz
Jul 1, 2020·Journal of Microbiological Methods·Israel Barbosa GuedesMarcos Bryan Heinemann
Jun 3, 2021·Tropical Medicine and Infectious Disease·Hannah M CranfordBethany Bradford
May 25, 2021·Comparative Immunology, Microbiology and Infectious Diseases·Israel Barbosa GuedesMarcos Bryan Heinemann
Aug 19, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Ana RabazaFederico Giannitti
Aug 24, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Sérgio Ricardo MaiolinoMárcio Garcia Ribeiro
Nov 7, 2021·Transboundary and Emerging Diseases·Luiza AyméeWalter Lilenbaum

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Methods Mentioned

BETA
urine collection
PCR
electrophoresis
urine

Software Mentioned

BioEdit
BLAST
WinEpi
Chromas
MEGA
GelAnalyzer

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