Abstract
The growth of Rickettsia prowazekii Madrid E was monitored in mouse L929 cells subcultured for several weeks in the presence of gamma interferon (IFN-gamma) to determine whether the rickettsiae would be eliminated from or would persist in these cultures. R. prowazekii exhibited two distinct patterns in these IFN-gamma-treated cultures. In some cases, IFN-gamma-induced inhibition of rickettsial growth led to elimination of the rickettsiae from the L929 cell cultures; in other cases, the initial inhibition of rickettsial growth was followed by establishment of a persistent rickettsial infection in the IFN-gamma-treated L929 cells. During the first 3 days after infection, the growth rate of the L929 cells was significantly lower and higher percentages of the cells were killed in the IFN-gamma-treated, R. prowazekii-infected cultures than in the untreated, R. prowazekii-infected cultures or the mock-infected cultures, whether treated or untreated. This suppression of cell growth occurred in the infected, IFN-gamma-treated cultures that eventually exhibited the elimination pattern as well as the IFN-gamma-treated cultures that became persistently infected. It was not possible to predict the outcome of a particular infection from the...Continue Reading
References
May 1, 1979·Journal of Clinical Microbiology·T S Walker, H H Winkler
Jul 1, 1986·Infection and Immunity·J Turco, H H Winkler
May 1, 1987·Infection and Immunity·H LiD H Walker
May 1, 1987·The American Journal of Tropical Medicine and Hygiene·B Hanson
Oct 1, 1973·Infection and Immunity·M R Gambrill, C L Wisseman
Dec 1, 1972·Antimicrobial Agents and Chemotherapy·E A Havell, J Vilcek
Jun 1, 1983·The Journal of Experimental Medicine·C L Wisseman, A Waddell
Mar 1, 1983·The Journal of Experimental Medicine·J Turco, H H Winkler
Oct 1, 1983·Infection and Immunity·J Turco, H H Winkler
Dec 1, 1983·The Journal of Experimental Medicine·J Turco, H H Winkler
Aug 1, 1984·Infection and Immunity·J Turco, H H Winkler
Jan 1, 1982·Annual Review of Microbiology·E Weiss
Mar 1, 1957·Journal of Bacteriology·E WEISSE C SUITOR
Jan 1, 1959·Journal of Bacteriology·E WEISSE C SUITOR
Sep 1, 1959·Journal of Bacteriology·E WEISSE C SUITOR
Feb 1, 1962·Journal of Bacteriology·E WEISS, H R DRESSLER
Apr 1, 1950·Journal of Bacteriology·M R BOVARNICKJ C SNYDER
Citations
Dec 1, 1990·FEMS Microbiology Immunology·A S Cross, N M Kelly
May 6, 1998·Parasite Immunology·A NyikaA F Barbet
Sep 28, 2017·MBio·Timothy P DriscollJoseph J Gillespie
Jan 1, 1990·Annals of the New York Academy of Sciences·J Turco, H H Winkler
Apr 1, 1994·Molecular Microbiology·H Pang, H H Winkler
Jan 1, 1994·Microbiology and Immunology·P Geng, T R Jerrells
May 1, 1996·Journal of Molecular Evolution·S G Andersson, P M Sharp
Jan 23, 2002·Vaccine·Aceme NyikaSuman M Mahan
May 1, 1991·Infection and Immunity·J Turco, H H Winkler
Oct 1, 1993·Infection and Immunity·J Turco, H H Winkler
Nov 1, 1991·Infection and Immunity·B Hanson
Aug 1, 1994·Infection and Immunity·J Turco, H H Winkler
May 1, 1994·Infection and Immunity·H M FengD H Walker
Jun 1, 1993·Journal of Bacteriology·H Pang, H H Winkler
Sep 1, 1993·Journal of Bacteriology·J Cai, H H Winkler
Nov 1, 1995·Journal of Clinical Microbiology·R VemulapalliS K Dutta
Oct 1, 1990·Infection and Immunity·J Turco, H H Winkler
Mar 31, 2009·Future Microbiology·Sanjeev K Sahni, Elena Rydkina