Isolation of Rickettsia prowazekii with reduced sensitivity to gamma interferon.

Infection and Immunity
J Turco, H H Winkler

Abstract

The growth of Rickettsia prowazekii Madrid E was monitored in mouse L929 cells subcultured for several weeks in the presence of gamma interferon (IFN-gamma) to determine whether the rickettsiae would be eliminated from or would persist in these cultures. R. prowazekii exhibited two distinct patterns in these IFN-gamma-treated cultures. In some cases, IFN-gamma-induced inhibition of rickettsial growth led to elimination of the rickettsiae from the L929 cell cultures; in other cases, the initial inhibition of rickettsial growth was followed by establishment of a persistent rickettsial infection in the IFN-gamma-treated L929 cells. During the first 3 days after infection, the growth rate of the L929 cells was significantly lower and higher percentages of the cells were killed in the IFN-gamma-treated, R. prowazekii-infected cultures than in the untreated, R. prowazekii-infected cultures or the mock-infected cultures, whether treated or untreated. This suppression of cell growth occurred in the infected, IFN-gamma-treated cultures that eventually exhibited the elimination pattern as well as the IFN-gamma-treated cultures that became persistently infected. It was not possible to predict the outcome of a particular infection from the...Continue Reading

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Citations

Dec 1, 1990·FEMS Microbiology Immunology·A S Cross, N M Kelly
Jan 1, 1990·Annals of the New York Academy of Sciences·J Turco, H H Winkler
Apr 1, 1994·Molecular Microbiology·H Pang, H H Winkler
May 1, 1996·Journal of Molecular Evolution·S G Andersson, P M Sharp
Jun 1, 1993·Journal of Bacteriology·H Pang, H H Winkler
Nov 1, 1995·Journal of Clinical Microbiology·R VemulapalliS K Dutta
Mar 31, 2009·Future Microbiology·Sanjeev K Sahni, Elena Rydkina

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