PMID: 6171102Jul 1, 1981Paper

Isolation of strain-specific and cross-reacting antibodies to influenza virus hemagglutinins from heterogenous populations of hyperimmune influenza sera

Voprosy virusologii
A L PlatonovaZ I Rovnova

Abstract

A population of monoreceptor cross-reacting antibodies to a common antigenic determinant H1.1 present on the surface of hemagglutinin molecules of H0, H1 and Hsw1 subtypes has been isolated from a heterogenous population of antihemagglutinating antibodies of influenza hyperimmune sera. Selective adsorption yields highly active strain-specific sera to HA of A/FM/1/47 and A/Netherlands/36/56 viruses. Populations of strain-specific antibodies to HA of A/Moscow/Pan/52 and A/USSR/090/77 viruses were found to be identical, attesting to the complete similarity of the antigenic composition of HA of these viruses. The hyperimmune serum of A/Brazil/11/78 virus was found to contain a population of strain-specific antibodies different from HA of other H1N1 viruses studied. This shows that drift variants of A/USSR/090/77 virus appeared in 1978.

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.