Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures

Genomics
N MiuraT Sugiyama

Abstract

The very recently found evolutionarily conserved DNA-binding domain of 100 amino acids, termed the fork head domain, emerged from a sequence comparison of the rat hepatocyte transcription factor HNF-3 alpha and the homeotic gene fork head of Drosophila. We previously isolated a new member of this family, the mesenchyme fork head-1 (MFH-1) gene, which is expressed in developing mesenchyme. Here we describe the isolation of the mouse (MFH-1) and human (FKHL14) chromosomal MFH-1 genes and the determination of the gene and protein structures of MFH-1. We found that the MFH-1 gene has no introns and that the identity of the amino acid sequences of mouse and human MFH-1 proteins is 94%. We also investigated the transcriptional activity of the mouse and human MFH-1 proteins and found that both proteins act as positive transactivators.

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Citations

Sep 25, 2014·American Journal of Medical Genetics. Part a·Carole SargentRobert P Erickson
May 24, 2014·Journal of the American Society of Nephrology : JASN·Bing HeKarl Tryggvason
Jul 24, 2020·International Journal of Molecular Sciences·Daniela TavianMatteo Bertelli
Sep 26, 2002·Developmental Biology·Peter Carlsson, Margit Mahlapuu
Oct 21, 2003·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Brian P BrooksThomas W Glover

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