Isolation of two hemorrhagic toxins from Crotalus basiliscus basiliscus (Mexican west coast rattlesnake) venom and their effect on blood clotting and complement

The International Journal of Biochemistry
O MolinaE D Rael

Abstract

1. Two hemorrhagic toxins of mol. wt 27,000 (B1) and 27,500 (B2) and pI 9.8 and 5.2 respectively were isolated from Crotalus basiliscus venom. 2. The two proteinases did not cross-react antigenically. 3. Both toxins caused hemorrhage in mice and each was capable of hydrolyzing hide power azure, casein, collagen and fibrin. 4. B1 hydrolyzed the A alpha, B beta and gamma chains of fibrinogen. B2 hydrolyzed the A alpha and B beta chains of fibrinogen, but not the gamma chain. 5. Both proteinases inactivated guinea pig complement.

References

Oct 19, 1976·Biochemistry·J S Lwebuga-MukasaP Taylor
Feb 20, 1976·Biochimica Et Biophysica Acta·C Ouyang, C M Teng
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·F S Markland, A Perdon
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Citations

Apr 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·S Y HuangS A Smith
Jan 1, 1994·Pharmacology & Therapeutics·J B Bjarnason, J W Fox
Nov 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·E D RaelJ Perez
May 1, 1997·The International Journal of Biochemistry & Cell Biology·T Chen, E D Rael
Sep 15, 2010·Toxicon : Official Journal of the International Society on Toxinology·Qian-Yun Sun, Juan Bao
Apr 5, 2011·Toxicon : Official Journal of the International Society on Toxinology·Jian-Fang GaoXiang Ji
Sep 27, 2019·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Benyamin ShahbaziMasoumeh Bagheri
Mar 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Alessandra StrokaAlbetiza Lôbo de Araújo

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