Isolation of two new bioactive sesquiterpene lactone glycosides from the roots of Ixeris dentata

Bioorganic & Medicinal Chemistry Letters
SeonJu ParkSeung Hyun Kim

Abstract

Two new sesquiterpene lactone glycosides, 3-O-β-d-glucopyranosyl-8-hydroxy-(1,5,6,7,11)-guaia-3,10(14)-dien-12,6-olide (1) and 3-O-β-d-glucopyranosyl-8-(4-hydroxyphenylacetyloxy)-(1.5.6,7)-guaia-3,10(14),11(13)-trien-12,6-olide (2), and 12 known sesquiterpene lactone derivatives (3-14) were isolated from the roots of Ixeris dentata. Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR and MS spectra data. All compounds were tested for their ability to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cell. 3-O-β-d-Glucopyranosyl-8-(4-hydroxyphenylacetyloxy)-(1.5.6,7)-guaia-3,10(14),11(13)-trien-12,6-olide (2) showed the most potent inhibitory activity at a concentration of 20μM.

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Citations

Apr 11, 2019·Natural Product Research·SeonJu ParkSeung Hyun Kim
Apr 4, 2018·Current Medicinal Chemistry·Haroon KhanAnupam Bishayee
Sep 24, 2019·Journal of Asian Natural Products Research·SeonJu ParkSeung Hyun Kim

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