Isolation of ugi four-component condensation primary adducts: a straightforward route to isocoumarins

Organic Letters
Cristina FaggiGloria Menchi

Abstract

Ugi four-component condensation (Ugi-4CC) between 2-formylbenzoic acid, phenacylamine dimethyl acetal, and isocyanides afforded 1H-isochromen-1-ones (isocoumarins). These products, where structure corresponds to the tautomeric enediamine form of the Ugi-4CC primary adducts, were stable enough to allow their isolation and characterization. Stable isocoumarins were also obtained by employing anilines as the amino component in the Ugi four-component condensation.

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Citations

Dec 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·András VáradiSusruta Majumdar
Oct 3, 2018·Organic & Biomolecular Chemistry·Loïc HabertIsabelle Gillaizeau
Aug 6, 2016·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Palanisamy RavichandiranYanlong Gu
Jan 10, 2012·The Journal of Organic Chemistry·Nicolas ChéronPaul Fleurat-Lessard
May 1, 2018·Accounts of Chemical Research·Qian WangJieping Zhu

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