PMID: 7017347Jan 1, 1981Paper

Isolation of yeast mutants sensitive to the bifunctional alkylating agent nitrogen mustard

Molecular & General Genetics : MGG
A RuhlandMartin Brendel

Abstract

Mutants of Saccharomyces cerevisiae with enhanced sensitivity to the DNA cross-linking agent nitrogen mustard (HN2) have been isolated and partially characterized with respect to their phenotypic and genetic properties. The screening technique, based on HN2-sensitivity as sole criterion, yields approxiamtely 1 sensitive isolate in 200 clones when applied to an intensively mutagenized population of a resistant parent strain. Mutants characterized so far are all due to recessive nuclear genes and represent at least seven complementation groups. They exhibit different degrees as well as different patterns of sensitivity towards monofunctional and bifunctional alkylating agents, and ultraviolet light.

References

Dec 1, 1979·Mutation Research·M KircherM Brendel
Oct 2, 1979·Molecular & General Genetics : MGG·R Fleer, M Brendel
Jan 1, 1975·Methods in Cell Biology·R K Mortimer, D C Hawthorne
Sep 12, 1973·Molecular & General Genetics : MGG·M Brendel, R H Haynes
Jan 1, 1970·Molecular & General Genetics : MGG·M BrendelR H Haynes

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Citations

Dec 1, 1990·Current Genetics·J A Henriques, M Brendel
Jan 1, 1986·Current Genetics·A RuhlandR H Haynes
Nov 1, 1981·Mutation Research·A RuhlandM Brendel
Jul 1, 1988·Mutation Research·H J BurtscherL B Couto
Feb 9, 2006·Chemical Reviews·David M NollPaul S Miller
Aug 24, 1999·Nucleic Acids Research·P J McHughJ A Hartley
Nov 22, 2011·Nucleic Acids Research·Tracy Tiefenbach, Murray Junop
Jun 17, 2003·Molecular and Cellular Biology·Sarah LambertPeter J McHugh
Apr 11, 2012·International Journal of Molecular Sciences·Samuel SaitoMartin Brendel
Dec 24, 2013·Journal of Photochemistry and Photobiology. B, Biology·Fernanda M MunariJoão A P Henriques
May 25, 2011·FEBS Letters·Elizabeth Garner, Agata Smogorzewska
Jun 4, 2015·International Journal of Molecular Sciences·Sônia C MeloMartin Brendel
Nov 17, 2007·DNA Repair·Ali HazratiPeter J McHugh
Feb 10, 2010·Environmental and Molecular Mutagenesis·Mitch McVey
Feb 23, 2010·Environmental and Molecular Mutagenesis·Emma CattellPeter J McHugh
Apr 1, 1983·Chemico-biological Interactions·M Kircher, M Brendel
Mar 2, 2005·Biochemical and Biophysical Research Communications·Seisuke KimuraKengo Sakaguchi
Nov 18, 2005·Computational Biology and Chemistry·Diego BonattoJoão Antonio Pêgas Henriques
Nov 14, 2006·FEMS Microbiology Reviews·Peter LehoczkýMiroslav Chovanec

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