PMID: 26338072Sep 5, 2015Paper

Isolation, Purification and Characterization of a Novel Steroidal Saponin Cholestanol Glucoside from Lasiodiplodia theobromae that Induces Apoptosis in A549 Cells

Anti-cancer Agents in Medicinal Chemistry
Jinu Mathew ValayilC Jayabaskaran

Abstract

Search for novel anticancer lead molecules continues to be a major focus of cancer research due to the limitations of existing drugs such as lack of tumor selectivity, narrow therapeutic index and multidrug resistance of cancer types. Natural molecules often possess better pharmacokinetic traits compared to synthetic molecules as they continually evolve by natural selection process to interact with biological macromolecules. Microbial metabolites constitute nearly half of the pharmaceuticals in market today. Endophytic fungi, owing to its rich chemical diversity, are viewed as attractive sources of novel bioactive compounds. In the present study, we report the purification and characterization of a novel steroidal saponin, cholestanol glucoside (CG) from Saraca asoca endophytic fungus Lasiodiplodia theobromae. The compound was assessed for its cytotoxic potentialities in six human cancer cell lines, A549, PC3, HepG2, U251, MCF7 and OVCAR3. CG exhibited significant cytotoxicities towards A549, PC3 and HepG2 among which A549 cells were most vulnerable to CG treatment. However, CG treatment exhibited negligible cytotoxicity in non malignant human lung fibroblast cell line (WI-38). Induction of cell death by CG treatment in A549 ce...Continue Reading

Citations

Aug 21, 2018·Natural Product Research·Blessing O UmeokoliPeter Proksch
Jan 11, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yogeswari SubramaniamJayabaskaran Chelliah
Oct 12, 2021·World Journal of Microbiology & Biotechnology·Omar Cabezas GómezJaine Honorata Hortolan Luiz

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