Isolation rearing as a preclinical model of attention/deficit-hyperactivity disorder.

Behavioural Brain Research
Justin R YatesMichael T Bardo

Abstract

Rats raised in an isolated condition (IC) are impulsive and hyperactive compared to rats raised in an enriched condition (EC), suggesting that isolation rearing may be a preclinical model of attention-deficit/hyperactivity disorder (ADHD). The current study determined if administration of methylphenidate (MPH), a dopamine transporter (DAT) blocker used in the treatment of ADHD, reduces the hyperactivity observed in IC rats toward levels observed in EC rats. Another goal was to determine if chronic MPH treatment differentially alters DAT function in EC and IC rats in medial prefrontal cortex (mPFC) or orbitofrontal cortex (OFC). IC and EC rats were treated with either MPH (1.5 mg/kg, p.o.) or vehicle from postnatal days (PND) 28-51. On PND 28 and 51, rats were evaluated for MPH-induced locomotor activity. On PND 55-63, in vitro [(3)H]DA uptake assays were performed in mPFC and OFC. At both PND 28 and 51, IC rats were hyperactive compared to EC rats. At PND 28, MPH increased activity in EC rats only. At PND 51, MPH did not alter locomotor activity in IC or EC rats. Beginning at PND 55, basal uptake of [(3)H]dopamine in IC rats was higher in mPFC and lower in OFC compared to EC rats. The basal differences in DAT function were norm...Continue Reading

References

Mar 18, 1977·Brain Research·D GaleyM Le Moal
Dec 1, 1983·Behavioural Brain Research·J P de BruinN Van de Poll
Jun 1, 1994·Pharmacology, Biochemistry, and Behavior·S L Bowling, M T Bardo
Jun 1, 1996·Behavioural Brain Research·M R Rosenzweig, E L Bennett
Apr 22, 1999·The British Journal of Psychiatry : the Journal of Mental Science·A ThaparR Harrington
Nov 9, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·S SprichS V Faraone
Jun 22, 2002·Pharmacology, Biochemistry, and Behavior·Nicole C A SchrijverHanno Würbel
Aug 1, 1964·The Journal of Comparative Neurology·M C DIAMONDM R ROSENZWEIG
Dec 4, 2003·Behavioural Brain Research·Kerry McAlonan, Verity J Brown
May 26, 2004·Brain Research. Developmental Brain Research·Kim G C HellemansMary C Olmstead
Jul 21, 2004·Journal of Neuroscience Methods·Jason M Williams, Jeffery D Steketee
Sep 17, 2004·The International Journal of Neuroscience·Behrang AminiNachum Dafny
May 24, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·James J McGoughSimon J Tulloch
Jun 14, 2005·Biological Psychiatry·Terje SagvoldenMehdi Farshbaf
Jun 14, 2005·Biological Psychiatry·Stephen V FaraonePamela Sklar
May 5, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jeffery N EpsteinUNKNOWN MTA Cooperative Study Group
May 9, 2006·Physiology & Behavior·David A WoodGeorge V Rebec
Aug 22, 2006·Nature Neuroscience·Peter H RudebeckMatthew F S Rushworth
Nov 23, 2006·Brain Research Bulletin·Pamela B YangNachum Dafny
Mar 6, 2007·Behavioural Brain Research·Vasileios BoulougourisTrevor W Robbins
Jun 7, 2008·Behavioural Brain Research·Jennifer L PerryMichael T Bardo
May 26, 2009·Pharmacology, Biochemistry, and Behavior·Dustin J Stairs, Michael T Bardo
Aug 28, 2009·Journal of the Neurological Sciences·Qin HongXia Chi
Nov 30, 2010·Behavioural Brain Research·Pamela B YangNachum Dafny
Dec 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roxann C HarveyKathleen M Kantak

❮ Previous
Next ❯

Citations

May 8, 2016·Alcoholism, Clinical and Experimental Research·Tracy R ButlerJeffrey L Weiner
Oct 5, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Seiwa MichiharaRyuji Takahashi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.