Isolation rearing impaired sensorimotor gating but increased pro-inflammatory cytokines and disrupted metabolic parameters in both sexes of rats

Psychoneuroendocrinology
Chih-Yuan Ko, Yia-Ping Liu

Abstract

Social isolation rearing (SIR) is an early stress paradigm of deprivation of the social contact since weaning. SIR has been used to investigate the mechanisms behind certain mental illnesses with neurodevelopmental origins, including schizophrenia. In schizophrenia, metabolic dysfunction has become a critical issue with increasing evidence for a possible connection between metabolism and immune systems in which metabolic changes are associated with pro-inflammatory cytokine (pro-CK) levels. The present study employed a rat model of SIR with both sexes to examine behaviors [locomotor activity and prepulse inhibition (PPI)], inflammatory markers [C-reactive protein, interleukin (IL)-1 beta, IL-6, IL-10, tumor necrosis factor (TNF)-alpha and interferon-gamma], and metabolism-related variables (body weight, blood pressure, and the profiles of glycemia and lipid). Our results revealed that around puberty, SIR rats of both sexes exhibited behaviorally a higher locomotor activity and a lower PPI performance. Biochemically, SIR rats had an elevated level of pro-CKs (IL-1 beta, IL-6, TNF-alpha, and interferon-gamma), and metabolic abnormalities (increased insulin resistance, decreased insulin sensitivity, and high blood pressure) in a t...Continue Reading

References

Sep 25, 1999·Physiology & Behavior·V P Bakshi, M A Geyer
Jun 14, 2002·Physiology & Behavior·Martha M Faraday
Jun 20, 2002·The Journal of Biological Chemistry·Katsutoshi Ozaki, Warren J Leonard
Feb 4, 2003·The American Journal of Psychiatry·Martina C M RyanJogin H Thakore
Apr 20, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anatoliy GladkevichJakob Korf
May 26, 2004·Brain Research. Developmental Brain Research·Kim G C HellemansMary C Olmstead
Jan 22, 2005·American Heart Journal·Phillippa J MirandaJohn R Guyton
Oct 27, 2006·Diabetes Research and Clinical Practice·Ilona MikkolaMarkku Timonen
Mar 27, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·L M SpelmanJ H Thakore
May 16, 2008·Epidemiologic Reviews·John McGrathJoy Welham
Jan 1, 1997·European Psychiatry : the Journal of the Association of European Psychiatrists·N MüllerM Ackenheil
Dec 31, 2009·European Journal of Clinical Investigation·P-S HsiehC-H Chen
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anindya DasguptaSonai Mandal
Mar 15, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yia-Ping LiuChe-Se Tung
Apr 1, 2011·British Journal of Pharmacology·C A JonesK C F Fone
Jun 7, 2011·Biological Psychiatry·Brian J MillerBrian Kirkpatrick
Jul 30, 2011·Psychiatry Research·Jaana SuvisaariAntti Jula
Nov 30, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Urs Meyer
Mar 6, 2012·Metabolism: Clinical and Experimental·Robert W O'RourkeDaniel L Marks
Apr 21, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michelle D Richard, Nancy C Brahm
Nov 9, 2012·International Journal of Biological Sciences·María ErtaJuan Hidalgo
Apr 8, 2014·Schizophrenia Research·Rachel UpthegroveNicholas M Barnes
Aug 16, 2014·Schizophrenia Research·Jakub TomasikSabine Bahn
Dec 9, 2014·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Kailash Prasad, Indu Dhar

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Citations

Feb 16, 2016·Psychoneuroendocrinology·Clemente Garcia-RizoMiquel Bernardo
Jan 19, 2016·Behavioural Brain Research·Chih-Yuan KoYia-Ping Liu
Jan 9, 2016·Neuroscience and Biobehavioral Reviews·Rachel Anne Hill
Jun 7, 2015·Medical Hypotheses·Yu-Yin YangYia-Ping Liu
May 8, 2016·Alcoholism, Clinical and Experimental Research·Tracy R ButlerJeffrey L Weiner
Sep 14, 2016·Behavioural Brain Research·Sharon S LanderInna Gaisler-Salomon
Jan 16, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L SchipperG van Dijk
Jun 1, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Carine LampertCarla Dalmaz
Jan 29, 2019·Frontiers in Neuroscience·Fabiana Corsi-ZuelliCristina Marta Del-Ben
Oct 6, 2020·Brain and Neuroscience Advances·Nichola M Brydges, Jack Reddaway
Jul 30, 2017·Brain Sciences·Alexandria Hicks-NelsonBenjamin C Nephew
Jan 8, 2021·PloS One·Flávia Alves VerzaDaniel Galera Bernabé
Oct 18, 2020·Molecular and Cellular Neurosciences·Jack Reddaway, Nichola M Brydges
Sep 1, 2020·Mechanisms of Ageing and Development·Annabelle PanossianMark S Yeoman
Mar 1, 2019·Molecular Neuropsychiatry·Hamidreza Famitafreshi, Morteza Karimian

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