Isolation, Structure elucidation, and antimycobacterial properties of dimeric naphtho-gamma-pyrones from the marine-derived fungus Aspergillus carbonarius

Chemistry & Biodiversity
Yapeng ZhangWei-Ming Zhu

Abstract

Two new dimeric naphtho-gamma-pyrones, compounds 1 and 2, were isolated from the AcOEt extract of the fungal strain WZ-4-11 of Aspergillus carbonarius, together with eight known analogues, including 10,10'-bifonsecin B (3), 6'-O-demethylnigerone (4), nigerone (5), isonigerone (6), fonsecin (7), rubrofusarin B (8), TMC 256A1 (9), and flavasperone (10). Their structures were elucidated by means of UV, CD, IR, and 1D- and 2D-NMR spectroscopy, in combination with HR-MS analysis. The fully assigned (1)H- and (13)C-NMR data of 3, and the (13)C-NMR data of 6 are reported for the first time. Compounds 1 and 2 showed weak antimycobacterial activities against Mycobacterium tuberculosis H37Rv, with MIC values of 43.0 and 21.5 microM, resp.

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Citations

May 28, 2013·Marine Biotechnology·Yoon Mi LeeJee H Jung
Sep 3, 2013·Indian Journal of Microbiology·Khouloud M Barakat, Yousry M Gohar
Mar 2, 2012·Organic and Medicinal Chemistry Letters·Mohamed ShaabanMohamed S Abdel-Aziz
Jun 3, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shiqiong LuLigang Zhou
Dec 19, 2014·Applied Microbiology and Biotechnology·Elodie ChoqueFlorence Mathieu
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Feb 19, 2013·Chemistry & Biodiversity·Zhiying WangWeiming Zhu
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Jan 14, 2011·Natural Product Reports·Mostafa E Rateb, Rainer Ebel

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