Isolectin B4 binding neurons are not present in the rat knee joint

Neuroscience
S P IvanaviciusP I Mapp

Abstract

Small-diameter sensory neurons are key contributors in joint pain and have been implicated in the pathogenesis of rheumatoid arthritis (RA). Small-diameter sensory neurons can be separated into at least two distinct populations, which include isolectin B4 (IB4)-binding and tyrosine receptor kinase (trk) A-expressing. While trkA-expressing neurons have been identified in the rat knee joint there are no data, we are aware of, to suggest that IB4-binding neurons are also present. We aimed to determine whether or not there exists a population of IB4-binding neurons in the rat knee joint. Retrograde nerve tracing with fluoro-gold (FG) was used to identify the complete population of knee joint afferents in the lumbar dorsal root ganglia (DRG) L3 and L4 of female Wistar rats. IB4 conjugated to fluorescein isothiocyanate (FITC) was used to identify the cell bodies of IB4-binding neurons in the DRG. Of 1096 FG-labeled cell bodies in the DRG of knee joint injected animals (n=4), none were double labeled with FITC. Injection of FG into skin over the medial aspect of the rat knee (n=3) showed 48% of these cutaneous afferents in L3 and L4 DRG were double-labeled with FG and FITC. A complete absence of IB4-binding neurons in the rat knee joi...Continue Reading

References

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Citations

Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Amalia Di CastroPaolo Cesare
Sep 8, 2010·Neuroscience Letters·Kentaro OnoKiyotoshi Inenaga
Feb 3, 2009·The Journal of Pain : Official Journal of the American Pain Society·Masahiko IkeuchiKathleen A Sluka
Jun 10, 2008·Brain Research·Won Gil Cho, Juli G Valtschanoff
Apr 30, 2015·British Journal of Clinical Pharmacology·David A WalshSara Kelly
Jun 30, 2006·European Journal of Pain : EJP·Kazuki KuniyoshiKazuhisa Takahashi
Sep 19, 2006·Molecular and Cellular Neurosciences·Sandra RebeloDeolinda Lima
Jul 26, 2005·Neuroscience Letters·Janet FernihoughJanet Winter
Aug 4, 2015·Current Osteoporosis Reports·Rachel E MillerAnne-Marie Malfait
Apr 1, 2016·Molecular Pain·Ines da Silva SerraEwan St John Smith
Aug 16, 2008·Clinical Orthopaedics and Related Research·Takayuki NakajimaYoshitada Harada
Feb 8, 2008·The Journal of Bone and Joint Surgery. British Volume·T NakajimaY Harada

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