Isoliquiritigenin ameliorates caerulein-induced chronic pancreatitis by inhibiting the activation of PSCs and pancreatic infiltration of macrophages.

Journal of Cellular and Molecular Medicine
Li-Juan WangLiang-Hao Hu

Abstract

Chronic pancreatitis (CP) is characterized by persistent inflammation of the pancreas that results in progressive loss of the endocrine and exocrine compartment owing to atrophy and/or replacement with fibrotic tissue. Currently, the clinical therapeutic scheme of CP is mainly symptomatic treatment including pancreatic enzyme replacement, glycaemic control and nutritional support therapy, lacking of specific therapeutic drugs for prevention and suppression of inflammation and fibrosis aggravating in CP. Here, we investigated the effect of isoliquiritigenin (ILG), a chalcone-type dietary compound derived from licorice, on pancreatic fibrosis and inflammation in a model of caerulein-induced murine CP, and the results indicated that ILG notably alleviated pancreatic fibrosis and infiltration of macrophages. Further in vitro studies in human pancreatic stellate cells (hPSCs) showed that ILG exerted significant inhibition on the proliferation and activation of hPSCs, which may be due to negative regulation of the ERK1/2 and JNK1/2 activities. Moreover, ILG significantly restrained the M1 polarization of macrophages (RAW 264.7) via attenuation of the NF-κB signalling pathway, whereas the M2 polarization was hardly affected. These fin...Continue Reading

References

Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C H CharlesN K Tonks
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Atsushi MasamuneTooru Shimosegawa
Apr 23, 2003·The Tohoku Journal of Experimental Medicine·Atsushi MasamuneTooru Shimosegawa
Apr 2, 2004·The Journal of Pharmacology and Experimental Therapeutics·Atsushi MasamuneTooru Shimosegawa
Jul 28, 2004·Journal of Herbal Pharmacotherapy·Eman G HaggagTheoharis C Theoharides
Feb 8, 2006·Journal of Molecular Endocrinology·T Zhang, M S Roberson
Oct 22, 2008·Oncogene·D N Dhanasekaran, E P Reddy
Aug 12, 2009·Cellular Signalling·Anna KucharskaStephen M Keyse
Jul 29, 2010·Seminars in Liver Disease·Thomas A Wynn, Luke Barron
Dec 21, 2010·Biochimica Et Biophysica Acta·Alexander PlotnikovRony Seger
Jul 10, 2012·Cell & Bioscience·Ching-Yu Huang, Tse-Hua Tan
Jul 10, 2012·Nature Medicine·Thomas A Wynn, Thirumalai R Ramalingam
Jul 21, 2012·The FEBS Journal·Christopher J Caunt, Stephen M Keyse
Jan 10, 2013·Annual Review of Immunology·Steven J Van Dyken, Richard M Locksley
Oct 9, 2013·The Journal of Experimental Medicine·Stephen J JenkinsJudith E Allen
May 20, 2015·Nature Communications·Jing XueAida Habtezion
Sep 1, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shanshan WuZhi Chen
Jun 20, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Hui TaoJun Li
Sep 8, 2017·Nature Reviews. Disease Primers·Jorg KleeffJohn P Neoptolemos
Jul 4, 2018·Frontiers in Physiology·Ran XueJianyu Hao
Jun 4, 2019·International Journal of Molecular Sciences·Hsueh-Fen ChenTse-Hua Tan
Jul 30, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xiang-Peng ZengLiang-Hao Hu

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Methods Mentioned

BETA
PCR
Illumina sequencing
nuclear translocation

Software Mentioned

R
GeneTools
GraphPad Prism
ImageJ

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