Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis through the inhibition of MAPK pathway

International Immunopharmacology
Young Hee ChoiYoung-Won Chin

Abstract

Isoliquiritigenin (isoLQ), a chalcone found in licorice, has shown a variety of biological activity including anti-inflammatory and antioxidative effects, and the distribution of isoLQ in gastrointestinal tract was higher than any other tissues. Thus, we evaluated whether or not isoLQ attenuated the dextran sulfate sodium (DSS)-induced colitis by observing the physiological changes (body weight loss, diarrhea, bleeding stool, overall disease activity index (DAI) scores, colon length), histopathological analysis and myeloperoxidase (MPO) activities of esophagus and colon. Also, the MAPK pathways including phosphorylation of ERK1/2, p38, and AKT, and the activation of NK-κB were evaluated in colon tissue. Interestingly, the reduction of body weight and colon length, increase of diarrhea, bloody stool, DAI scores and MPO activity, and histologic disturbances in DSS-induced colitis were recovered by isoLQ treatment. Also, isoLQ treatment suppressed the phosphorylation of ERK1/2 and p38, and the activation of NK-κB compared to those in DSS-induced colitis mice. In addition, the distributions of isoLQ in colon were relatively higher in DSS-induced colitis models. All of these results suggested that isoLQ has potential activity to ame...Continue Reading

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Citations

Aug 31, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Xinxin ChenShousong Huo
Jul 12, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Chunyan WangLi Zhang
Aug 29, 2018·The American Journal of Chinese Medicine·Xiaxia WuXiuping Chen
Apr 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Danni WangXin Chai
Jan 27, 2021·Planta medica·Byoung Hoon YouYoung Hee Choi
Jan 7, 2021·Cancers·Kai-Lee WangShih-Min Hsia
Dec 17, 2019·Current Pharmaceutical Biotechnology·Mehdi ZobeiriSeyed Mohammad Nabavi

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