Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity

BMC Neuroscience
Xiaobo ZhuOu Chen

Abstract

Oxidative stress and neuroinflammation are central pathogenic mechanisms common to many neurological diseases. Isoliquiritigenin (ISL) is a flavonoid in licorice with multiple pharmacological properties, including anti-inflammatory activity, and has demonstrated protective efficacy against acute neural injury. However, potential actions against cognitive impairments have not been examined extensively. We established a rat model of cognitive impairment by intracerebroventricular injection of lipopolysaccharide (LPS), and examined the effects of ISL pretreatment on cognitive function, hippocampal injury, and hippocampal expression of various synaptic proteins, antioxidant enzymes, pro-inflammatory cytokines, and signaling factors controlling anti-oxidant and pro-inflammatory responses. Rats receiving LPS alone demonstrated spatial learning deficits in the Morris water maze test as evidenced by longer average escape latency, fewer platform crossings, and shorter average time in the target quadrant than untreated controls. ISL pretreatment reversed these deficits as well as LPS-induced decreases in the hippocampal expression levels of synaptophysin, postsynaptic density-95, brain-derived neurotrophic factor, superoxide dismutase, g...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 7, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chun Zhan, Jing Yang
Aug 23, 2008·Antioxidants & Redox Signaling·Marcus J CalkinsJeffrey A Johnson
Jan 10, 2009·Journal of Agricultural and Food Chemistry·Bolleddula JayaprakasamXiu-Min Li
Jan 27, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·S H LeeD H Sohn
Jun 6, 2009·Circulation Research·Magdalena JuhaszovaSteven J Sollott
Oct 17, 2009·Journal of Pharmacological Sciences·Min Jung LeeMeeyul Hwang
Apr 20, 2010·Pharmacology, Biochemistry, and Behavior·Qi-Hai GongYi-Zhun Zhu
Oct 28, 2010·JAMA : the Journal of the American Medical Association·Theodore J IwashynaKenneth M Langa
Mar 28, 2012·Bioscience, Biotechnology, and Biochemistry·Cheol Kyu Hwang, Hong Sung Chun
Jul 24, 2013·Journal of Neurochemistry·Sarah J BertrandRosemarie M Booze
Sep 3, 2014·Journal of Neuroinflammation·David J Allison, David S Ditor
Apr 25, 2015·Phytotherapy Research : PTR·Fu PengJianping Chen
Sep 19, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yangping WuJinliang Yang
Dec 3, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Isabel DenzerKristina Friedland
Jul 23, 2016·Nature Reviews. Neurology·Katherine C NickelsElaine C Wirrell
Jan 23, 2017·Journal of Neuroinflammation·Wei-Xing ZhaoWei-Dong Mi
Feb 9, 2017·Cellular and Molecular Neurobiology·Alok TripathiSairam Krishnamurthy
Oct 5, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Beita ZhaoXuebo Liu
Nov 28, 2017·Neuroscience and Biobehavioral Reviews·Jack CotterJennifer H Barnett

❮ Previous
Next ❯

Citations

Feb 12, 2021·Bioorganic Chemistry·Pritam ThapaMukut Sharma
Apr 2, 2021·The Journal of Pharmacy and Pharmacology·Sharifa AlzahraniNehal M Elsherbiny
Jul 28, 2021·Journal of Chemical Neuroanatomy·Mohammadmehdi Hassanzadeh-TaheriMehran Hosseini

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA
enzyme-linked immunosorbent assay
ELISA
nuclear translocation
protein assay
PCR

Software Mentioned

SPSS

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here