Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1/Nrf2 pathway and inhibiting the NF-κB and NLRP3 pathways in carrageenan-induced pleurisy

Food & Function
Yun GaoXinxin Ci

Abstract

Pleurisy refers to a pleural disease caused by pathogenic factors that stimulate the pleura associated with pleural inflammation and oxidative stress. Isoliquiritigenin (ISL), a flavonoid from the liquorice compound, possesses antioxidative and anti-inflammatory properties. In the current study, we investigated the protective effects of ISL on carrageenan-induced pleurisy and lung injury in mice. The mice were intraperitoneally injected with ISL (30 mg kg-1) twice (each time interval of 12 h), followed by exposure to Car 1 h after the second dose of ISL. Our results indicated that ISL treatment significantly alleviated carrageenan-induced histopathological damage and increased levels of inflammatory cell exudation, protein leakage, and pro-inflammatory mediators. Meanwhile, ISL inhibited reactive oxygen species (ROS) generation, MDA and MPO formation, and SOD and GSH depletion induced by carrageenan. In addition, it decreased the GSSG level and GSSG-to-GSH ratio. In terms of the mechanism, ISL inhibited NOX2 and NOX4 levels, caused the dissociation of KEAP-1 and Nrf2, and activated the downstream genes HO-1, NQO1, GCLC and GCLM, thus decreasing oxidative stress. In addition, ISL exerts protective effects against inflammation by...Continue Reading

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Citations

Oct 1, 2020·Critical Reviews in Food Science and Nutrition·Davi Vieira Teixeira da SilvaVania Margaret Flosi Paschoalin
Jan 6, 2021·International Journal of Molecular Sciences·Fumiko Sekiguchi, Atsufumi Kawabata
Jan 7, 2021·Cancers·Kai-Lee WangShih-Min Hsia
Feb 6, 2021·Carbohydrate Polymers·Jia-Li JiangJing-Wei Shao
Feb 5, 2021·Biomedicines·Baolong Liu, Jiujiu Yu
Dec 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hanbyeol MoonSang Woo Kim
Feb 24, 2021·Journal of Agricultural and Food Chemistry·Xingqi WangRuiqin Yao
Jul 21, 2021·Bioengineered·Yu-Chen LiaoJo-Shu Chang

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
nuclear magnetic resonance
ELISA
flow cytometry
MDA
nuclear translocation

Software Mentioned

ImageJ
GraphPad Prism

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