Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling

Frontiers in Pharmacology
Man ZhangDa-Qing Chen

Abstract

Severe acute pancreatitis (SAP) is a digestive system disease that is associated with a range of complications including intestinal dysfunction. In this study, we determined that the chalcone compound, isoliquiritigenin (ISL), reduces pancreatic and intestinal injury in a mouse model of SAP. These effects were achieved by suppressing oxidative stress and the inflammatory responses to SAP. This was evidenced by a reduction in histological score, and malondialdehyde (MDA), interleukin (IL)-6, tumor necrosis factor (TNF)-α and cleaved-caspase-3 (c-caspase-3) protein along with an increase in Nrf2, hemeoxygenase-1 (HO-1), quinone oxidoreductase 1 (NQO1), and superoxide dismutase (SOD). We then used Nrf2-/- mice to test the protective effect of Nrf2 during ISL treatment of SAP. Our results indicated that Nrf2-/- mice had greater pancreatic injury and intestinal dysfunction than wild-type mice. They also had reduced adherens junctions (P120-catenin) and tight junctions (occludin), and increased activated nuclear factor-κB (NF-κB) protein. In Nrf2-/- mice, ISL was less effective at these functions than in the WT mice. In conclusion, this study demonstrated that ISL exerts its protective effects against oxidative stress and inflammator...Continue Reading

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Citations

Apr 24, 2020·Oxidative Medicine and Cellular Longevity·Weiwei ChenWeiqin Li
Nov 18, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Walaa Yehia AbdelzaherMaha Yehia Kamel
Mar 12, 2021·Expert Review of Clinical Pharmacology·Melford Chuka EgbujorLuciano Saso

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
Polymerase Chain Reaction
MDA

Software Mentioned

ImageJ
GraphPad Pro

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