Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression

Diabetes
J W RyderK L Houseknecht

Abstract

Conjugated linoleic acid (CLA) isomers have a number of beneficial health effects, as shown in biomedical studies with animal models. Previously, we reported that a mixture of CLA isomers improved glucose tolerance in ZDF rats and activated peroxisome proliferator-activated receptor (PPAR)-gamma response elements in vitro. Here, our aim was to elucidate the effect(s) of specific CLA isomers on whole-body glucose tolerance, insulin action in skeletal muscle, and expression of genes important in glucose and lipid metabolism. ZDF rats were fed either a control diet (CON), one of two CLA supplemented diets (1.5% CLA) containing differing isoforms of CLA (47% c9,t11; 47.9% c10,t12, 50:50; or 91% c9,t11, c9,t11 isomers), or were pair-fed CON diet to match the intake of 50:50. The 50:50 diet reduced adiposity and improved glucose tolerance compared with all other ZDF treatments. Insulin-stimulated glucose transport and glycogen synthase activity in skeletal muscle were improved with 50:50 compared with all other treatments. Neither phosphatidlyinositol 3-kinase activity nor Akt activity in muscle was affected by treatment. Uncoupling protein 2 in muscle and adipose tissue was upregulated by c9,t11 and 50:50 compared with ZDF controls....Continue Reading

References

Dec 1, 1991·Acta Physiologica Scandinavica·E J Henriksen, J O Holloszy
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M J CharronH F Lodish
Jan 28, 1993·The New England Journal of Medicine·M BorkmanL V Campbell
Mar 7, 1998·The Journal of Biological Chemistry·M ShimabukuroR H Unger
Apr 16, 1998·Biochemical and Biophysical Research Communications·K L HouseknechtM A Belury
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M HigaR H Unger
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·R H Unger

❮ Previous
Next ❯

Citations

Dec 18, 2001·Diabetes/metabolism Research and Reviews·B NazlielB Koçer
Jan 31, 2006·Journal of Physiology and Biochemistry·M A ZuletJ A Martínez
May 9, 2009·European Journal of Nutrition·Ganesh V HaladeGabriel Fernandes
May 8, 2003·Lipids·Ulf RisérusBengt Vessby
Mar 20, 2003·Current Diabetes Reports·C J Segal-IsaacsonJ Wylie-Rosett
Sep 25, 2003·Metabolism: Clinical and Experimental·Mary K TeacheyErik J Henriksen
Oct 18, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S O'Hagan, A Menzel
Mar 20, 2002·Domestic Animal Endocrinology·Karen L HouseknechtPamela J Steele
Nov 15, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yoko TakahashiTakashi Ide
Jul 20, 2002·The International Journal of Biochemistry & Cell Biology·Petr Jezek
Jul 23, 2009·The British Journal of Nutrition·Robert Ringseis, Klaus Eder
Jul 22, 2009·The British Journal of Nutrition·Jonatan MirandaMaría Puy Portillo
Feb 3, 2012·Nutrition Research Reviews·Tracy A McCrorieM Barbara E Livingstone
Feb 23, 2011·The Journal of Biological Chemistry·Johannes SchmidtEvi Kostenis
Jun 18, 2005·The Proceedings of the Nutrition Society·Sabine TriconParveen Yaqoob
Jan 12, 2001·Journal of the American College of Nutrition·J A Scimeca, G D Miller
Jan 13, 2006·Critical Reviews in Food Science and Nutrition·J Bruce German, Cora J Dillard
Aug 21, 2010·Archives of Animal Nutrition·Henry JørgensenKirsten Jakobsen
Jun 5, 2002·Current Opinion in Lipidology·Sebastiano Banni
Sep 19, 2009·Nutrition & Metabolism·Sailas Benjamin, Friedrich Spener
May 6, 2003·Journal of Lipid Research·J Mark BrownMichael K McIntosh

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.