Isoniazid-induced acute liver failure during preventive therapy for latent tuberculosis infection

Internal Medicine
Shoichi MiyazawaMitsuhiko Moriyama

Abstract

Treating latent tuberculosis infection is a strategy for eliminating tuberculosis, and isoniazid is recommended as preventive therapy. However, concerns have been raised regarding the application of isoniazid due to its toxicity, particularly hepatotoxicity; however, biochemical monitoring is not routinely performed during treatment. We herein present a case of fatal isoniazid-induced acute liver failure. The patient's liver function was not periodically examined and isoniazid therapy was continued for 10 days despite the onset of symptoms associated with hepatitis. The patient died four months after hospitalization. It is essential to consider the potential toxicities of isoniazid and establish strategies to prevent acute liver failure.

References

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Citations

Mar 12, 2016·International Journal of Mycobacteriology·Lingaraja Jena, Bhaskar C Harinath
Sep 21, 2016·Case Reports in Infectious Diseases·Wissam K KabbaraPaola G Saroufim
Jan 28, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yong LianShuang-Qing Peng
Jul 28, 2016·Human & Experimental Toxicology·E ElmorsyW G Carter
Aug 14, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·M NogueiraT Torres
Aug 4, 2018·Pharmacology Research & Perspectives·Mulugeta RussomTeklezghi Teklesenbet

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