Isoniazid-related hepatitis

Digestive Diseases
R Vasudeva, B Woods

Abstract

Conclusive evidence of isoniazid (INH)-related hepatotoxicity ranging from asymptomatic elevation of liver enzymes to fulminant hepatic failure resulting in liver transplantation and/or death has been firmly established. Anticipation of the widespread usage of INH in the prevention and treatment of tuberculosis is expected due to the recent increasing incidence of tuberculosis. The aim of this article is to review the current concepts of pathogenesis, histopathology, risk factors and clinical features of INH-related hepatitis, emphasizing the need for vigilance.

Citations

Feb 18, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Umberto CilloDavide Francesco D'Amico
Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stanislas PolAnais Vallet-Pichard
Jan 31, 2002·World Journal of Gastroenterology : WJG·S R BramhallJ A Buckels

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