Isoniazid@Fe2 O3 Nanocontainers and Their Antibacterial Effect on Tuberculosis Mycobacteria

Angewandte Chemie
Peter LeidingerClaus Feldmann

Abstract

Isoniazid-filled Fe2 O3 hollow nanospheres (INH@Fe2 O3 , diameter <30 nm, 48 wt % INH-load) are prepared for the first time and suggested for tuberculosis therapy. After dextran-functionalization, the INH@Fe2 O3 @DEX nanocontainers show strong activity against Mycobacterium tuberculosis (M.tb.) and M.tb.-infected macrophages. The nanocontainers can be considered as "Trojan horses" and show efficient, active uptake into both M.tb.-infected macrophages and even into mycobacterial cells.

References

Nov 20, 2004·Nature Reviews. Microbiology·Ulrich E Schaible, Stefan H E Kaufmann
Oct 26, 2007·Nano Letters·Daniel H M Buchold, Claus Feldmann
Dec 22, 2007·Nanomedicine·Jennifer B HallScott E McNeil
Jan 15, 2009·Angewandte Chemie·Kristina RiehemannHarald Fuchs
Oct 13, 2009·International Journal of Pharmaceutics·Gaurav Kant SaraogiG P Agrawal
Nov 17, 2009·Advanced Drug Delivery Reviews·Alejandro SosnikDiego A Chiappetta
Oct 13, 2010·Nature Reviews. Microbiology·Gareth GriffithsGopal K Khuller
Mar 25, 2011·Current Medicinal Chemistry·A K SharmaS S Sandhu
Oct 22, 2011·Tuberculosis·Sujatha M Santhanagopalan, G Marcela Rodriguez
May 25, 2012·Medicinal Research Reviews· Beena, Diwan S Rawat
Sep 19, 2012·Advanced Materials·Patrick William GoodwillSteven M Conolly
Nov 10, 2012·Science·Hal Drakesmith, Andrew M Prentice
Feb 6, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Behrooz Zargar, Amir Hatamie
May 1, 2013·Nature Reviews. Drug Discovery·Alimuddin ZumlaStewart T Cole
May 3, 2013·ACS Nano·Lénaic LartigueFlorence Gazeau
May 28, 2013·ACS Nano·Claudia GottsteinJoseph Anthony Zasadzinski
Jul 11, 2013·Nanomedicine·Yanping DingGuangjun Nie
Dec 18, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Admire DubeGene D Morse
Jan 24, 2014·Nature Materials·Chun Li
Jan 24, 2014·Nature Materials·Daishun LingTaeghwan Hyeon
Jan 28, 2014·Tuberculosis·Pedro PedrosaPedro V Baptista
Nov 25, 2014·Nano Today·Sandra ChapmanLily Yang
Dec 30, 2014·The Lancet Global Health·Alimuddin ZumlaMatt Oliver
Feb 24, 2015·Immunological Reviews·Günter Weiss, Ulrich E Schaible
Jan 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mani GajendiranSengottuvelan Balasubramanian

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Citations

Nov 20, 2016·Angewandte Chemie·Silke Wolf, Claus Feldmann
Jun 21, 2019·Current Pharmaceutical Design·Prasad MinakshiGaya Prasad
Nov 7, 2017·Journal of Basic Microbiology·Alireza JafariAli Majidpour
Mar 13, 2020·International Journal of Nanomedicine·Nelly HéraultKatharina M Fromm
Feb 21, 2019·Biomacromolecules·Jiří TrousilMartin Hrubý

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