Isopentenyl pyrophosphate-reactive Vgamma9Vdelta 2 T helper 1-like cells are the major gammadelta T cell subset recovered from lesions of patients with genital herpes

The Journal of Infectious Diseases
Georges M G M VerjansAlbert 'D M E Osterhaus

Abstract

Herpes simplex virus (HSV)-specific T cells are essential to control and resolve genital herpes (GH). To investigate the potential involvement of gamma delta T cells in GH, T cells were recovered and expanded, by mitogenic stimulation, to T cell lines from the genital lesions of 17 patients with GH and 5 control subjects who had other diseases. Relatively high numbers of gamma delta T cells--predominantly, V gamma 9V delta 2 T cells--were detected only in the T cell lines of the patients with GH. Intralesional V gamma 9V delta 2 T cell clones did not recognize HSV-infected cells, but they showed reactivity to isopentenyl pyrophosphate and Daudi cells. The T cell clones secreted interferon- gamma, tumor necrosis factor- alpha, interleukin (IL)-8, macrophage inflammatory protein-1 alpha, and RANTES (regulated on activation, normally T cell expressed or secreted), but they secreted no or limited IL-4. The results of the present study suggest the infiltration and putative involvement of isopentenyl pyrophosphate-reactive V gamma 9V delta 2 T helper 1-like cells in individuals with GH.

Citations

Jan 12, 2008·Annual Review of Medicine·David M Koelle, Lawrence Corey
Dec 13, 2005·Current Opinion in Immunology·Willi K BornRebecca L O'Brien
Mar 18, 2015·Immunology and Cell Biology·Maud Deruaz, Andrew D Luster
Jan 1, 2013·Annual Review of Animal Biosciences·Jeff HoldernessMark A Jutila
Aug 28, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Claire DevilderEmmanuel Scotet
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Serge BarcyLawrence Corey
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles T SpencerDaniel F Hoft

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