Isopeptide bond in collagen- and fibrinogen-binding MSCRAMMs

Biophysics Reviews
Upasana Sridharan, Karthe Ponnuraj

Abstract

The internal isopeptide bonds are amide bonds formed autocatalytically between the side chains of Lys and Asn/Asp residues and have been discovered recently. These bonds are well conserved in Gram-positive bacterial pilin proteins and are also observed over a wide range of Gram-positive bacterial surface proteins. The presence of these bonds confers the pilus subunits with remarkable properties in terms of thermal stability and resistance to proteases. Like pili, microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) are also surface proteins found only in Gram-positive bacteria. They specifically interact with the extracellular matrix (ECM) molecules like collagen, fibrinogen, fibronectin, laminin, etc. Many biophysical and biochemical studies have been carried out to characterize the isopeptide bonds in pili proteins from Gram-positive bacteria, but no attempts have been made to study the isopeptide bonds in MSCRAMMs. This short review aims to study the significance of the isopeptide bonds in relation to their function, by analyzing the crystal structures of collagen- and fibrinogen-binding MSCRAMMs. In this analysis, interestingly, we observed that the putative isopeptide bonds are restricted to the co...Continue Reading

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Citations

Nov 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Zhong QianSankar Adhya
Apr 12, 2020·The Journal of Biological Chemistry·Anna H Bizard, Ian D Hickson
May 17, 2017·Biophysics Reviews·Cris Dos Remedios
Mar 31, 2018·Science·Lukas F MillesRafael C Bernardi
Feb 29, 2020·The Journal of Biological Chemistry·Frederic Chedin, Craig J Benham
May 6, 2019·International Journal of Molecular Sciences·Daniel HatlemJack C Leo
Mar 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ivan E IvanovZev Bryant
Dec 2, 2020·Nature Chemistry·Alvaro Alonso-CaballeroJulio M Fernandez
Aug 20, 2020·The Journal of Physical Chemistry. B·Piotr FilipiakBronislaw Marciniak

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