Abstract
To examine the effect of isoprenaline on slow and fast pathway properties and tachycardia initiation. Consecutive patients, prospective study. Referral centre for cardiology, academic hospital. 24 patients suffering from common type atrioventricular nodal reentrant tachycardia (AVNRT). Programmed electrical stimulation and radiofrequency catheter ablation of the slow pathway. AVNRT was induced before and after the administration of isoprenaline in nine patients (group 1), before isoprenaline only in five (group 2), and after isoprenaline only in 10 (group 3). The anterograde effective refractory period of the fast pathway was prolonged significantly during isoprenaline administration in group 1 (405 (31) v 335 (34) ms, p < 0.001) and shortened in group 2 (308 (57) v 324 (52) ms, p = 0.005). There was also significant shortening in group 3 (346 (85) v 395 (76) ms, p < 0.001). Isoprenaline administration did not result in a significant change of the anterograde effective refractory period of the slow pathway in groups 1 and 3, but eliminated slow pathway conduction in group 2. Isoprenaline significantly shortened the minimal and maximal atrial to His bundle conduction interval recording in response to each extrastimulus of the sl...Continue Reading
Citations
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