PMID: 9950Aug 1, 1975

Isoprenaline antagonism of cardioselective beta-adrenergic receptor blocking agents on human and rat adipocytes

British Journal of Clinical Pharmacology
H H Harms, J Van der Meer

Abstract

1. The beta-adrenergic blocking potencies of practolol, ICI 66082, tolamolol, acebutolol, H 93/26, H 87/07, pindolol and Ro 3-4787 were compared with that of propranolol, on human and rat adipocytes. 2. A good correlation was found between the potencies on adipocytes of the two species but not between our results and literature data on antagonism of isopernaline tachycardia in the anaesthetized cat. 3. The results indicate that differences between adrenergic beta-receptors in heart and adipose tissue may be detected using cardioselective beta-adrenergic receptor blocking agents.

References

Feb 1, 1973·Life Sciences. Pt. 1: Physiology and Pharmacology·B AbladL Ek
Jun 1, 1973·British Journal of Pharmacology·B BasilD R Maxwell
Jan 1, 1974·European Journal of Pharmacology·H H HarmsB Van der Wal
Feb 1, 1974·European Journal of Pharmacology·K R AdamJ Linnell
Aug 1, 1967·Analytical Biochemistry·H Ko, M E Royer

Citations

May 4, 1984·European Journal of Pharmacology·C WilsonJ R Arch
Jun 5, 1992·European Journal of Pharmacology·T SugasawaA D Strosberg
Apr 6, 2002·Reproductive Toxicology·Sonia A Tabacova, Carole A Kimmel
Nov 1, 1993·Medicinal Research Reviews·J R Arch, A J Kaumann
Jan 1, 1982·British Journal of Clinical Pharmacology·H H HarmsJ Zaagsma

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