Isoprenoid glycosides from Liriosma ovata

Journal of Natural Products
Patrizia PicernoRita Aquino

Abstract

A methanol extract of the dried bark of Liriosma ovata afforded two new isoprenoid glycosides, a eudesmane sesquiterpene, 1alpha(beta- d-glucopyranosyloxy)eudesma-3alpha,4beta, 11-triol ( 1), and a C 13-norisoprenoid, 3alpha,6alpha-dihydroxymegastigman-7-en-9-one 3- O-beta- d-apiofuranosyl-(1-->6)-beta- d-glucopyranoside ( 2), as well as a known constituent, isopropyl-beta- d-apiofuranosyl-(1-->6)-beta- d-glucopyranoside ( 3). The structures of 1 and 2 were determined using spectroscopic methods. The methanol extract had a significant topical anti-inflammatory activity (ID 50, dose inducing 50% edema inhibition = 780 microg/cm (2)) about 8 times less than that of indomethacin (ID 50, 93 microg/cm (2)) assayed by the croton oil ear test in mice. In addition, the chloroform extract and compounds 1 and 2 showed weak antimicrobial activity against S taphylococcus aureus (MIC = 5.1, 2.1, and 4.0 mg/mL, respectively) using a broth microdilution assay.

References

Jan 1, 1986·Agents and Actions·A TubaroR Della Loggia
Mar 1, 1994·Journal of Ethnopharmacology·M L VillarrealG Delgado
May 26, 2001·Journal of Natural Products·T J HsiehY C Wu
Jul 28, 2001·Journal of Natural Products·J ChangJ S Zhang
Aug 25, 2001·Journal of Natural Products·R AquinoA Tomaino
Dec 28, 2002·Journal of Natural Products·Rita AquinoLuca Rastrelli
Feb 5, 2004·Phytochemistry·Yoshio TakedaHideaki Otsuka
Dec 29, 2004·Journal of Natural Products·Zhihua SunChangqi Hu
Feb 15, 2005·Journal of Ethnopharmacology·Maher M Al-DabbasHideo Hayashi

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Citations

Apr 26, 2012·Journal of Asian Natural Products Research·Xi-Dian YueSheng-Jun Dai
Nov 4, 2009·Phytochemistry·Dahai MengWeimin Zhao
Jan 15, 2015·Journal of Natural Products·Jun MaAlexander J Krynitsky
Aug 21, 2009·Natural Product Reports·Braulio M Fraga
May 10, 2019·Magnetic Resonance in Chemistry : MRC·Qian LiJinfu Wan

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