Isopropyl Caffeate: A Caffeic Acid Derivative-Antioxidant Potential and Toxicity

Oxidative Medicine and Cellular Longevity
Andressa Brito LiraHilzeth de Luna Freire Pessôa

Abstract

Phenolic compounds, among them isopropyl caffeate, possess antioxidant potential, but not without toxicity and/or adverse effects. The present study aimed to evaluate the antioxidant activity and toxicity of isopropyl caffeate through in silico, in vitro and in vivo testing. The results showed that isopropyl caffeate presents no significant theoretical risk of toxicity, with likely moderate bioactivity: GPCR binding, ion channel modulation, nuclear receptor binding, and enzyme inhibition. Isopropyl caffeate induced hemolysis only at the concentrations of 500 and 1000 μg/ml. We observed types A and O erythrocyte protection from osmotic stress, no oxidation of erythrocytes, and even sequestrator and antioxidant behavior. However, moderate toxicity, according to the classification of GHS, was demonstrated through depressant effects on the central nervous system, though there was no influence on water and food consumption or on weight gain, and it did present possible hepatoprotection. We conclude that the effects induced by isopropyl caffeate are due to its antioxidant activity, capable of preventing production of free radicals and oxidative stress, a promising molecule with pharmacological potential.

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Citations

Jul 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Susiany P LopesDamião P de Sousa
Nov 30, 2019·International Journal of Molecular Sciences·Susiany P LopesDamião P de Sousa
Dec 10, 2019·International Journal of Medicinal Chemistry·Merly de Armas-RicardOney Ramírez-Rodríguez
Jan 21, 2021·Archives of Oral Biology·Waleska Ohana de Souza-MeloJozinete Vieira Pereira
Feb 27, 2021·Drug and Chemical Toxicology·Camila Bomfim de SáMargareth de Fátima Formiga Melo Diniz

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